Activity-Dependent Adjustments of the Inhibitory Network in the Adult Olfactory Bulb Following Early Postnatal Deprivation (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Activity-Dependent Adjustments of the Inhibitory Network in the Adult Olfactory Bulb Following Early Postnatal Deprivation (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.neuron.2005.02.016 (literal)

Alternative label

• Saghatelyan A.; Roux P.; Migliore M.; Rochefort C.; Desmaisons D.; Charneau P.; Shepherd G.M.; Lledo P-M (2005)
  Activity-Dependent Adjustments of the Inhibitory Network in the Adult Olfactory Bulb Following Early Postnatal Deprivation
  in Neuron (Camb. Mass.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Saghatelyan A.; Roux P.; Migliore M.; Rochefort C.; Desmaisons D.; Charneau P.; Shepherd G.M.; Lledo P-M (literal)

Pagina inizio

• 103 (literal)

Pagina fine

• 113 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 46 (literal)

Rivista

• Neuron (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1)Laboratory of Perception and Memory, Pasteur Institute, Centre National de la Recherche, Scientifique (URA 2182), 75015 Paris Cedex, France 2) Platform of Dynamic Imaging, Pasteur Institute, 25 rue du Dr. Roux, 75015 Paris Cedex, France 3) Department of Neurobiology, Yale Medical School, 333 Cedar Street, New Haven, Connecticut 06510, and CNR Institute of Biophysics, Palermo, Italy 4) Laboratory of Molecular Virology and Vectorology, Pasteur Institute, 28 rue du Dr. Roux, 75724 Paris, France (literal)

Titolo

• Activity-Dependent Adjustments of the Inhibitory Network in the Adult Olfactory Bulb Following Early Postnatal Deprivation (literal)

Abstract

• The first-order sensory relay for olfactory processing, the main olfactory bulb (MOB), retains the ability to acquire new interneurons throughout life. It is therefore a particularly appropriate region for studying the role of experience in sculpting neuronal networks. We found that nostril closure decreased the number of newborn granule cells in the MOB, the complexity of their dendritic arborization, and their spine density, without affecting the preexisting population of granule cells. Accordingly, the frequency of miniature synaptic inhibitory events received by mitral cells was reduced. However, due to a compensatory increase in newborn granule cell excitability, action potential-dependent GABA release was dramatically enhanced, thus counteracting the reduction in spine density and leading to an unaltered synchronization of mitral cell firing activity. Together, this study reveals a unique form of adaptive response brought about exclusively by the cohort of newborn cells and used to maintain normal functioning of the MOB. (literal)

Prodotto di

• Modelli di Organizzazione e Dinamica di Sistemi Complessi (MD.P01.004.001) (Modulo)
• Istituto di biofisica (IBF) (Istituto)

Autore CNR

• MICHELE MIGLIORE (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Activity-Dependent Adjustments of the Inhibitory Network in the Adult Olfactory Bulb Following Early Postnatal Deprivation" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di biofisica (IBF) (Istituto)
• Modelli di Organizzazione e Dinamica di Sistemi Complessi (MD.P01.004.001) (Modulo)

Autore CNR di

• MICHELE MIGLIORE (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Neuron (Rivista)

Insieme di parole chiave di

• Keywords of "Activity-Dependent Adjustments of the Inhibitory Network in the Adult Olfactory Bulb Following Early Postnatal Deprivation" (Insieme di parole chiave)