http://www.cnr.it/ontology/cnr/individuo/prodotto/ID9411
On the integration of subthreshold inputs from Perforant Path (Articolo in rivista)
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- On the integration of subthreshold inputs from Perforant Path (Articolo in rivista) (literal)
- Anno
- 2003-01-01T00:00:00+01:00 (literal)
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- ISI Web of Science (WOS) (literal)
- Titolo
- On the integration of subthreshold inputs from Perforant Path (literal)
- Abstract
- Using a realistic model of a CA1 hippocampal pyramidal neuron, we make experimentally testable predictions on the roles of the non-specific cation current, I(h), and the A-type Potassium current, I(A), in modulating the temporal window for the integration of the two main excitatory afferent pathways of a CA1 neuron, the Schaffer Collaterals and the Perforant Path. The model shows that the experimentally observed increase in the dendritic density of I(h) and I(A) could have a major role in constraining the temporal integration window for these inputs, in such a way that a somatic action potential (AP) is elicited only when they are activated with a relative latency consistent with the anatomical arrangement of the hippocampal circuitry.
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