http://www.cnr.it/ontology/cnr/individuo/prodotto/ID9168
Polymerisation of hemoglobins in Arctic fish: Lycodes reticulatus and Gadus morhua. (Articolo in rivista)
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- Polymerisation of hemoglobins in Arctic fish: Lycodes reticulatus and Gadus morhua. (Articolo in rivista) (literal)
- Anno
- 2011-01-01T00:00:00+01:00 (literal)
- Alternative label
Alessia Riccio1, Gaetano Mangiapia2, Daniela Giordano1, Angela Flagiello3, Roberta Tedesco3, Stefano Bruno4, Alessandro Vergara2,5, Lelio Mazzarella2,5, Guido di Prisco1, Piero Pucci3,6, Luigi Paduano2 and Cinzia Verde1 (2011)
Polymerisation of hemoglobins in Arctic fish: Lycodes reticulatus and Gadus morhua.
in IUBMB life (Print)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Alessia Riccio1, Gaetano Mangiapia2, Daniela Giordano1, Angela Flagiello3, Roberta Tedesco3, Stefano Bruno4, Alessandro Vergara2,5, Lelio Mazzarella2,5, Guido di Prisco1, Piero Pucci3,6, Luigi Paduano2 and Cinzia Verde1 (literal)
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- PMID: 21491556
http://onlinelibrary.wiley.com/doi/10.1002/iub.450/abstract (literal)
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- ISI Web of Science (WOS) (literal)
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- 1Institute of Protein Biochemistry, CNR, Via Pietro Castellino 111, Naples, Italy
2Department of Chemistry, University of Naples ''Federico II,'' Complesso Universitario Monte S. Angelo, Via Cinthia, Naples, Italy
3CEINGE Biotecnologie Avanzate, Universita` di Napoli ''Federico II,'' Via G. Salvatore 486, Napoli
4Dipartimento di Biochimica e Biologia Molecolare, Universita` di Parma, Viale G.P. Usberti 23/A, Parma, Italy
5Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, Naples, Italy
6Department of Organic Chemistry and Biochemistry, University of Naples ''Federico II,'' Naples, Italy (literal)
- Titolo
- Polymerisation of hemoglobins in Arctic fish: Lycodes reticulatus and Gadus morhua. (literal)
- Abstract
- In vitro, and possibly in vivo, hemoglobin polymerization and red blood cell sickling appear to be widespread in codfish. In this article, we show that the hemoglobins of the two Arctic fish Lycodes reticulatus and Gadus morhua also have the tendency to polymerize, as monitored by dynamic light scattering experiments. The elucidation of the primary structure of the single hemoglobin of the zoarcid L. reticulatus shows the presence of a large number of cysteyl residues in ± and ² chains. Their role in eliciting the ability to produce polymers was also addressed by MALDI-TOF and TOF-TOF mass spectrometry. The G.morhua globins are also rich in Cys, but unlike in L. reticulatus, polymerization does not seem to be disulfide driven. The widespread occurrence of the polymerization phenomenon displayed by hemoglobins of Arctic fish supports the hypothesis that this feature may bea response to stressful environmental conditions. (literal)
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