Faciogenital dysplasia protein Fgd1 regulates invadopodia biogenesis and extracellular matrix degradation and is upregulated in prostate and breast cancer (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Faciogenital dysplasia protein Fgd1 regulates invadopodia biogenesis and extracellular matrix degradation and is upregulated in prostate and breast cancer (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Alternative label

• Ayala I, Giacchetti G, Caldieri G, Attanasio F, Mariggiò S, Tetè S, Polishchuk R, Castronovo V, Buccione R (2009)
  Faciogenital dysplasia protein Fgd1 regulates invadopodia biogenesis and extracellular matrix degradation and is upregulated in prostate and breast cancer
  in Cancer research (Chic. Ill.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Ayala I, Giacchetti G, Caldieri G, Attanasio F, Mariggiò S, Tetè S, Polishchuk R, Castronovo V, Buccione R (literal)

Pagina inizio

• 747 (literal)

Pagina fine

• 752 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 69(3) (literal)

Rivista

• Cancer research (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• PubMed N. e link: PMID: 19141649 http://www.ncbi.nlm.nih.gov/pubmed/19141649 (literal)

Note

• ISI Web of Science (WOS) (literal)

Titolo

• Faciogenital dysplasia protein Fgd1 regulates invadopodia biogenesis and extracellular matrix degradation and is upregulated in prostate and breast cancer (literal)

Abstract

• Invadopodia are proteolytically active membrane protrusions that extend from the ventral surface of invasive tumoral cells grown on an extracellular matrix (ECM). The core machinery controlling invadopodia biogenesis is regulated by the Rho GTPase Cdc42. To understand the upstream events regulating invadopodia biogenesis, we investigated the role of Fgd1, a Cdc42-specific guanine nucleotide exchange factor. Loss of Fgd1 causes the rare inherited human developmental disease faciogenital dysplasia. Here, we show that Fgd1 is required for invadopodia biogenesis and ECM degradation in an invasive cell model and functions by modulation of Cdc42 activation. We also find that Fgd1 is expressed in human prostate and breast cancer as opposed to normal tissue and that expression levels matched tumor aggressiveness. Our findings suggest a central role for Fgd1 in the focal degradation of the ECM in vitro and, for the first time, show a connection between Fgd1 and cancer progression, proposing that it might function during tumorigenesis. (literal)

Prodotto di

• Institute of protein biochemistry (IBP) (Istituto)
• Dr.ssa CORDA Meccanismi molecolari coinvolti nella trasformazione neoplastica: identificazione di bersagli specifici per lo sviluppo di nuovi farmaci (SV.P15.014.001) (Modulo)

Autore CNR

• STEFANIA MARIGGIO' (Persona)
• MARIA INMACULADA AYALA GRANDE (Persona)

Incoming links:

Prodotto

• Institute of protein biochemistry (IBP) (Istituto)
• Dr.ssa CORDA Meccanismi molecolari coinvolti nella trasformazione neoplastica: identificazione di bersagli specifici per lo sviluppo di nuovi farmaci (SV.P15.014.001) (Modulo)

Autore CNR di

• MARIA INMACULADA AYALA GRANDE (Persona)
• STEFANIA MARIGGIO' (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Cancer research (Rivista)