Lipid transfer protein (Ara h 9) as a new peanut allergen relevant for a mediterranean allergic population (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Lipid transfer protein (Ara h 9) as a new peanut allergen relevant for a mediterranean allergic population (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.jaci.2009.06.008 (literal)

Alternative label

• Krause S.; Reese G.; Randow S.; Zennaro D.; Quarantino D.; Palazzo P.; Ciardiello M.A.; Petersen A.; Becker W.M.; Mari A. (2009)
  Lipid transfer protein (Ara h 9) as a new peanut allergen relevant for a mediterranean allergic population
  in Journal of allergy and clinical immunology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Krause S.; Reese G.; Randow S.; Zennaro D.; Quarantino D.; Palazzo P.; Ciardiello M.A.; Petersen A.; Becker W.M.; Mari A. (literal)

Pagina inizio

• 771 (literal)

Pagina fine

• 778.e5 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 124 (literal)

Rivista

• Journal of allergy and clinical immunology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 4 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Research Center Borstel; Paul-Ehrlich-Institut, Langen; Center for Clinical and Experimental Allergology, IDI-IRCCS, Rome; Institute of Protein Biochemistry, CNR, Naples. (literal)

Titolo

• Lipid transfer protein (Ara h 9) as a new peanut allergen relevant for a mediterranean allergic population (literal)

Abstract

• Background: Nonspecific lipid transfer proteins (LTPs) represent potent pollen and food allergens. However, the allergenic properties of peanut LTP have not been studied. Objective: To identify LTP in peanut extract using sera from subjects with peanut allergy and Pru p 3–sensitized subjects from Southern Europe, clone and express this protein, and obtain information on the importance as allergen for these selected patients. Methods: Peanut LTP (Ara h 9) was cloned and sequenced by using a combination of bioinformatic and molecular biology tools (PCR, immunoblotting, Basic Local Alignment Search Tool [BLAST] searches). The immunologic properties of Ara h 9, Ara h 1, Ara h 2, and Ara h 3 were studied by using sera from subjects with peanut and peach allergy from Italy by immunoblotting and allergen microarray technology. Results: Two Ara h 9 isoforms—Ara h 9.01 and Ara h 9.02—were cloned and expressed. Ara h 9 represented a minor allergen for subjects with peanut allergy. However, including Ara h 9 as single component for serologic detection of sensitization to peanut by component-resolved diagnosis seems crucial, because the frequency of sensitization to the classic major peanut allergens Ara h 1, Ara h 2, and Ara h 3 was low in these patients from Southern Europe. Conclusion: Ara h 9 is a new member of the LTP allergen family that seems to play an important role in peanut allergy for patients from the Mediterranean area. (literal)

Prodotto di

• DR. MANCO : Studi di idrolasi da fonti diverse e proteine vegetali. (SV.P14.010.001) (Modulo)
• DR. DE BERARDINIS: SV.P03.006 (SV.P14.003.001) (Modulo)
• Institute of protein biochemistry (IBP) (Istituto)

Autore CNR

• MARIA ANTONIETTA CIARDIELLO (Persona)

Insieme di parole chiave

• Parole chiave di "Lipid transfer protein (Ara h 9) as a new peanut allergen relevant for a mediterranean allergic population" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of protein biochemistry (IBP) (Istituto)
• DR. DE BERARDINIS: SV.P03.006 (SV.P14.003.001) (Modulo)
• DR. MANCO : Studi di idrolasi da fonti diverse e proteine vegetali. (SV.P14.010.001) (Modulo)

Autore CNR di

• MARIA ANTONIETTA CIARDIELLO (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of allergy and clinical immunology (Rivista)

Insieme di parole chiave di

• Parole chiave di "Lipid transfer protein (Ara h 9) as a new peanut allergen relevant for a mediterranean allergic population" (Insieme di parole chiave)