Behaviour of human mesenchymal stem cells on a polyelectrolyte-modified HEMA hydrogel for silk-based ligament tissue engineering. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Behaviour of human mesenchymal stem cells on a polyelectrolyte-modified HEMA hydrogel for silk-based ligament tissue engineering. (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1163/156856208785540145 (literal)

Alternative label

• Bosetti M, Boccafoschi F, Calarco A, Leigheb M, Gatti S, Piffanelli V, Peluso G, Cannas M. (2008)
  Behaviour of human mesenchymal stem cells on a polyelectrolyte-modified HEMA hydrogel for silk-based ligament tissue engineering.
  in Journal of biomaterials science. Polymer ed. (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Bosetti M, Boccafoschi F, Calarco A, Leigheb M, Gatti S, Piffanelli V, Peluso G, Cannas M. (literal)

Pagina inizio

• 1111 (literal)

Pagina fine

• 1123 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 19 (literal)

Rivista

• Journal of biomaterials science. Polymer ed. (Rivista)

Note

• Google Scholar (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• IBP-CNR DiSCAFF, University of Eastern Piedmont A. Avogadro, Novara, Italy. (literal)

Titolo

• Behaviour of human mesenchymal stem cells on a polyelectrolyte-modified HEMA hydrogel for silk-based ligament tissue engineering. (literal)

Abstract

• The aim of this study was to design a functional bio-engineered material to be used as scaffold for autologous mesenchymal stem cells in ligament tissue engineering. Polyelectrolyte modified HEMA hydrogel (HEMA-co-METAC), applied as coating on silk fibroin fibres, has been formulated in order to take advantage of the biocompatibility of the polyelectrolyte by increasing its mechanical properties with silk fibres. Human bone marrow mesenchymal stem cells behaviour on such reinforced polyelectrolyte has been studied by evaluating cell morphology, cell number, attachment, spreading and proliferation together with collagen matrix production and its mRNA expression. Silk fibroin fibres matrices with HEMA-co-METAC coating exhibited acceptable mechanical behaviour compared to the natural ligament, good human mesenchymal stem cell adhesion and with mRNA expression studies higher levels of collagen types I and III expression when compared to control cells on polystyrene. These data indicate high expression of mRNA for proteins responsible for the functional characteristics of the ligaments and suggest a potential for use of this biomaterial in ligament tissue-engineering applications. (literal)

Prodotto di

• Institute of protein biochemistry (IBP) (Istituto)
• DR. PELUSO: Nanotecnologie applicate alla terapia genica e cellulare (PM.P02.014.001) (Modulo)

Autore CNR

• GIANFRANCO PELUSO (Persona)
• ANNA CALARCO (Persona)
• ORSOLINA PETILLO (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Behaviour of human mesenchymal stem cells on a polyelectrolyte-modified HEMA hydrogel for silk-based ligament tissue engineering." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• GIANFRANCO PELUSO (Persona)
• ANNA CALARCO (Persona)
• ORSOLINA PETILLO (Unità di personale interno)

Prodotto

• Institute of protein biochemistry (IBP) (Istituto)
• DR. PELUSO: Nanotecnologie applicate alla terapia genica e cellulare (PM.P02.014.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of biomaterials science. Polymer ed. (Rivista)

Insieme di parole chiave di

• Keywords of "Behaviour of human mesenchymal stem cells on a polyelectrolyte-modified HEMA hydrogel for silk-based ligament tissue engineering." (Insieme di parole chiave)