pRb2/p130 gene overexpression induces astrocyte differentiation. (Articolo in rivista)

Type
Label
  • pRb2/p130 gene overexpression induces astrocyte differentiation. (Articolo in rivista) (literal)
Anno
  • 2001-01-01T00:00:00+01:00 (literal)
Alternative label
  • Galderisi U., Melone M.A, Jori F.P., Piegari E., Di Bernardo G., Cipollaro M., Cascino A., Peluso G., Claudio P.P., Giordano A. (2001)
    pRb2/p130 gene overexpression induces astrocyte differentiation.
    in Molecular and cellular neurosciences (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Galderisi U., Melone M.A, Jori F.P., Piegari E., Di Bernardo G., Cipollaro M., Cascino A., Peluso G., Claudio P.P., Giordano A. (literal)
Pagina inizio
  • 415 (literal)
Pagina fine
  • 425 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 17 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Titolo
  • pRb2/p130 gene overexpression induces astrocyte differentiation. (literal)
Abstract
  • There are many data on the activity of the RB gene in neural differentiation and apoptosis, but the role of pRb2/p130 in neuronal and glial maturation has been far less investigated. To elucidate the role of pRb2/p130 in astrocyte development we overexpressed this protein in astrocytoma and normal astrocyte cultures by adenoviral-mediated gene transfer. In astrocytoma cells, p130/RB2 overexpression resulted in a significant reduction of cell growth and in an increased G(0)/G(1) cell population. We did not observe any induction of programmed cell death as determined by TUNEL reaction. Interestingly, pRb2/p130 overexpression induced astrocyte differentiation. Astrocyte cell cycle arrest and differentiation seemed to proceed through a way distinct from the p53 pathway. (literal)
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