http://www.cnr.it/ontology/cnr/individuo/prodotto/ID81444

Four-wavelength time-resolved optical mammograph (Contributo in atti di convegno)

Type

Prodotto della ricerca (Classe)
Contributo in atti di convegno (Classe)

Label

Four-wavelength time-resolved optical mammograph (Contributo in atti di convegno) (literal)

Anno

2003-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1117/12.478134 (literal)

Alternative label

Cubeddu, Rinaldo; Danesini, Gian Maria; Messina, Fabrizio; Pifferi, Antonio; Spinelli, Lorenzo; Taroni, Paola; Torricelli, Alessandro (2003)
Four-wavelength time-resolved optical mammograph
in Optical Tomography and Spectroscopy of Tissue V, San Jose, CA; United States, 26 - 29 January 2003
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Cubeddu, Rinaldo; Danesini, Gian Maria; Messina, Fabrizio; Pifferi, Antonio; Spinelli, Lorenzo; Taroni, Paola; Torricelli, Alessandro (literal)

Pagina inizio

203 (literal)

Pagina fine

210 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

http://www.scopus.com/record/display.url?eid=2-s2.0-0344420325&origin=inward (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

4955 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#volumeInCollana

4955 (literal)

Rivista

Proceedings of SPIE, the International Society for Optical Engineering (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

in: (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

8 (literal)

Note

Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Politecnico di Milano; Dipartimento di Radiologia (literal)

Titolo

Four-wavelength time-resolved optical mammograph (literal)

Abstract

An instrument for time-resolved optical mammography was constructed and is regularly used in an ongoing clinical trial. The system operates with four pulsed diode lasers emitting at 685, 785, 915, and 975 nm. The breast is slightly compressed between two Plexiglas plates and scanned along the X and Y directions. Light transmitted through the breast is collected by a 5 mm diameter optical bundle and coupled into two compact photomultipliers with enhanced sensitivity in the visible and near infrared spectral region, respectively. A multichannel PC board for time-correlated single photon counting is used for signal processing. Continuous acquisition and on line display of the processed images permit optimal measurement efficiency and control of the operation. A typical optical examination complies measurements obtained on both breasts in cranio-caudal and oblique projections, with a typical measurement time of 5 minutes for each scan. In this paper we demonstrate the feasibility of in vivo time-resolved optical mammograms acquired at wavelengths longer than 900 nm in the lipid and water absorption region. The results of a clinical trial performed on 101 patients are shown, demonstrating capability to discriminate between benign and malignant breast lesions on the basis of the different spectral behaviors. Furthermore, a non-linear perturbation model was successfully applied to the in vivo characterization of breast lesions. Preliminary results on tissue constituent determination (in term of blood volume, blood oxygen saturation, lipids and water content) were presented. (literal)

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