Modulation of MCP-1 and iNOS by 50-Hz sinusoidal electromagnetic field (Articolo in rivista)

Type
Label
  • Modulation of MCP-1 and iNOS by 50-Hz sinusoidal electromagnetic field (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Alternative label
  • Reale, M; De Lutiis, MA; Patruno, A; Speranza, L; Felaco, M; Grilli, A; Macri, MA; Comani, S; Conti, P; Di Luzio, S (2006)
    Modulation of MCP-1 and iNOS by 50-Hz sinusoidal electromagnetic field
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Reale, M; De Lutiis, MA; Patruno, A; Speranza, L; Felaco, M; Grilli, A; Macri, MA; Comani, S; Conti, P; Di Luzio, S (literal)
Pagina inizio
  • 50 (literal)
Pagina fine
  • 57 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 15 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Univ Chieti, Dept Oncol & Neurosci, Chieti, Italy; Univ Chieti, Dept Biomorphol, Chieti, Italy; Univ Chieti, Dept Clin Sci & Bioimaging, Chieti, Italy; Univ Chieti, Univ Fdn GD Annunzio, ITAB, Chieti, Italy; Univ Roma La Sapienza, Dept Expt Med & Pathol, Rome, Italy; INFM, CRS SOFT, Rome, Italy (literal)
Titolo
  • Modulation of MCP-1 and iNOS by 50-Hz sinusoidal electromagnetic field (literal)
Abstract
  • The purpose of this study was to investigate whether overnight exposure to 1 mT-50 Hz extremely low-frequency sinusoidal electromagnetic field (EMF) affects the expression and production of inducible nitric oxide synthase (iNOS) and monocyte chemotactic protein-1 (MCP-1) in human monocytes. RT-PCR and Western blot analysis demonstrate that EMF exposure affects the expression of iNOS and MCP-1 in cultured human mononuclear cells at the mRNA level and protein synthesis. Interestingly, the effects of EMF exposure clearly differed with respect to the potentiation and inhibition of iNOS and MCP-1 expression. Whereas iNOS was down-regulated both at the mRNA level and at the protein level, MCP-1 was up-regulated. These results provide helpful information regarding the EMF-mediated modulation of the inflammatory response in vivo. However, additional studies are necessary to demonstrate that EMF acts as a nonpharmacological inhibitor of NO and inducer of MCP-1 in some diseases where the balance of MCP-1 and NO may be important. (c) 2005 Elsevier Inc. All rights reserved. (literal)
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Autore CNR di
Prodotto
Insieme di parole chiave di
data.CNR.it