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Direct evidence of multicompartment aggregates in polyelectrolyte-charged liposome complexes (Articolo in rivista)

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Direct evidence of multicompartment aggregates in polyelectrolyte-charged liposome complexes (Articolo in rivista) (literal)

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Bordi, F; Cametti, C; Sennato, S; Diociaiuti, M (2006)
Direct evidence of multicompartment aggregates in polyelectrolyte-charged liposome complexes
in Biophysical journal (Print)
(literal)

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Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy; Ist Nazl Fis Mat, Ctr Ric & Sviluppo SOFT, Rome, Italy; Ist Super Sanita, Dipartimento Tecnol & Salute, I-00161 Rome, Italy (literal)

Titolo

Direct evidence of multicompartment aggregates in polyelectrolyte-charged liposome complexes (literal)

Abstract

By means of the combined use of dynamic light scattering and transmission electron microscopy measurements, we provide a direct evidence for the existence of an equilibrium cluster phase in the polyion-induced liposome aggregation, where the liposomes maintain their integrity, with the ability of preserving the aqueous core content from the external medium. We prepared single liposomes containing, in their interior, different CsCl electrolyte solutions at different concentrations (0.1 and 0.01 M, respectively). During the polyion-induced complexation of a mixture of these two differently loaded liposomes, reversible aggregates form, whose multicompartmental structure reveals the simultaneous presence of nonfused liposomes. Clusters composed by mesoscopic-sized vesicles and realized by charged lipids coupled to oppositely charged polyions are playing an increasingly important role as model systems in a variety of phenomena in soft matter and for their potential use in biomedical applications as drug delivery systems. Aggregates of liposomes such as those described in this article, where the electrostatic interactions are the primary driving forces promoting aggregation, may represent a new and interesting class of colloids which give rise to a rich phenomenology with several unusual colloidal behaviors that deserve to be further investigated. (literal)

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