http://www.cnr.it/ontology/cnr/individuo/prodotto/ID7133
Dynamics of tumour cords following changes in oxygen availability: a model including a delayed exit from quiescence (Articolo in rivista)
- Type
- Label
- Dynamics of tumour cords following changes in oxygen availability: a model including a delayed exit from quiescence (Articolo in rivista) (literal)
- Anno
- 2005-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.mcm.2005.05.007 (literal)
- Alternative label
Bertuzzi, A. (a); Fasano, A. (b); Filidoro, L. (a); Gandolfi, A. (a); Sinisgalli, C. (a) (2005)
Dynamics of tumour cords following changes in oxygen availability: a model including a delayed exit from quiescence
in Mathematical and computer modelling
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Bertuzzi, A. (a); Fasano, A. (b); Filidoro, L. (a); Gandolfi, A. (a); Sinisgalli, C. (a) (literal)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- a. CNR - Istituto di analisi dei sistemi ed informatica \"Antonio Ruberti\", 00185 Rome, Italy
b. Università degli studi di Firenze - Dipartimento di Matematica Ulisse Dini, 50134 Florence, Italy (literal)
- Titolo
- Dynamics of tumour cords following changes in oxygen availability: a model including a delayed exit from quiescence (literal)
- Abstract
- this paper, we investigate the formation of tumour cords (cylindrical arrangements
of tumour cells around blood vessels) within a tumour tissue. The shrinkage and the expansion of the
cord following a stepwise decrease or, respectively, increase of oxygen tension in the blood vessel are
also described. The model represents the tumour cell population as a continuum and includes two
novel aspects with respect to our previous works: cell death does not occur instantaneously, but is
preceded by a reversible prenecrotic state; the recruitment of cells from quiescence into proliferation
may require a recovery period. Model predictions are compared with experimental data reported by
Hirst et al. [1]. (literal)
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