GALT Protein Database, a Bioinformatics Resource for the Management and Analysis of Structural Features of a Galactosemia-related Protein and Its Mutants (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• GALT Protein Database, a Bioinformatics Resource for the Management and Analysis of Structural Features of a Galactosemia-related Protein and Its Mutants (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/S1672-0229(08)60035-2 (literal)

Alternative label

• d'Acierno A.; Facchiano A.; Marabotti A. (2009)
  GALT Protein Database, a Bioinformatics Resource for the Management and Analysis of Structural Features of a Galactosemia-related Protein and Its Mutants
  in Genomics, Proteomics & Bioinformatics; Academic Press Elsevier, Amsterdam (Paesi Bassi)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• d'Acierno A.; Facchiano A.; Marabotti A. (literal)

Pagina inizio

• 71 (literal)

Pagina fine

• 76 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 7 (literal)

Rivista

• Genomics, Proteomics & Bioinformatics (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1-2 (literal)

Note

• PubMe (literal)
• Scopu (literal)
• Google Scholar (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Laboratory of Bioinformatics and Computational Biology, Institute of Food Science, Italian National Research Council (CNR), 83100 Avellino, Italy (literal)

Titolo

• GALT Protein Database, a Bioinformatics Resource for the Management and Analysis of Structural Features of a Galactosemia-related Protein and Its Mutants (literal)

Abstract

• We describe the GALT-Prot database and its related web-based application that have been developed to collect information about the structural and functional effects of mutations on the human enzyme galactose-1-phosphate uridyltransferase (GALT) involved in the genetic disease named galactosemia type I. Besides a list of missense mutations at gene and protein sequence levels, GALT-Prot reports the analysis results of mutant GALT structures. In addition to the structural information about the wild-type enzyme, the database also includes structures of over 100 single point mutants simulated by means of a computational procedure, and the analysis to each mutant was made with several bioinformatics programs in order to investigate the effect of the mutations. The web-based interface allows querying of the database, and several links are also provided in order to guarantee a high integration with other resources already present on the web. Moreover, the architecture of the database and the web application is flexible and can be easily adapted to store data related to other proteins with point mutations. GALT-Prot is freely available at http://bioinformatica.isa.cnr.it/GALT/. (literal)

Editore

• Academic Press Elsevier (Editore)

Prodotto di

• Bioinformatica per lo studio di patologie umane, intolleranze alimentari e sicurezza alimentare (INT.P02.006.001) (Modulo)
• Applicazioni web-based per la creazione, la gestione e l’integrazione di data base di interesse biologico (INT.P02.005.002) (Modulo)
• Institute of food sciences (ISA) (Istituto)

Autore CNR

• ANGELO FACCHIANO (Unità di personale interno)
• ANNA MARABOTTI (Unità di personale interno)
• ANTONIO D'ACIERNO (Persona)

Insieme di parole chiave

• Parole chiave di "GALT Protein Database, a Bioinformatics Resource for the Management and Analysis of Structural Features of a Galactosemia-related Protein and Its Mutants" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of food sciences (ISA) (Istituto)
• Bioinformatica per lo studio di patologie umane, intolleranze alimentari e sicurezza alimentare (INT.P02.006.001) (Modulo)
• Applicazioni web-based per la creazione, la gestione e l’integrazione di data base di interesse biologico (INT.P02.005.002) (Modulo)

Autore CNR di

• ANTONIO D'ACIERNO (Persona)
• ANGELO FACCHIANO (Unità di personale interno)
• ANNA MARABOTTI (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Genomics, Proteomics & Bioinformatics (Rivista)

Editore di

• Academic Press Elsevier (Editore)

Insieme di parole chiave di

• Parole chiave di "GALT Protein Database, a Bioinformatics Resource for the Management and Analysis of Structural Features of a Galactosemia-related Protein and Its Mutants" (Insieme di parole chiave)