Cross-linked ionomeric materials from poly(styrene-alt-maleic anhydride) and poly(ethylene glycol) for biomedical applications: A preliminary investigation (Articolo in rivista)

Type
Label
  • Cross-linked ionomeric materials from poly(styrene-alt-maleic anhydride) and poly(ethylene glycol) for biomedical applications: A preliminary investigation (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Alternative label
  • Guerra G.D.1, Barbani N.2, Coluccio M.L.2, Cristallini C.1 (2006)
    Cross-linked ionomeric materials from poly(styrene-alt-maleic anhydride) and poly(ethylene glycol) for biomedical applications: A preliminary investigation
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Guerra G.D.1, Barbani N.2, Coluccio M.L.2, Cristallini C.1 (literal)
Pagina inizio
  • 97 (literal)
Pagina fine
  • 101 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 4 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • Biocompatible cross-linked ionimers, useful for drug delivery, blood purification and ion exchange (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1CNR Institute for Composite and Biomedical Materials, Section of Pisa, Pisa, Italy . 2Department of Chemical Engineering, Industrial Chemistry and Materials Science, University of Pisa, Pisa, Italy (literal)
Titolo
  • Cross-linked ionomeric materials from poly(styrene-alt-maleic anhydride) and poly(ethylene glycol) for biomedical applications: A preliminary investigation (literal)
Abstract
  • Two ionomeric materials, cross-linked through the formation of polyoxyethylene bridges, were synthesized by the reaction of poly(styrene-alt-maleic anhydride with poly(ethylene glycol), carried out in the absence of external catalysts. The reaction was carried out at room temperature, both in bulk with excess of glycol, and in acetone solution with a 20:1 anhydride rings to hydroxyl groups ratio. The materials were characterised by scanning electron microscopy (SEM), total reflection Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The SEM shows a quite uniform porous structure for the material synthesized in bulk, and two distinct phases for that synthesized in acetone solution, a sponge-like structure and a denser one. The FTIR spectra show that the first material has undergone the cross-linking reaction to a greater extent than the second one. Both TGA and DSC confirm the formation of cross-linked structures. Such tri-dimensional networks, owing to the presence of the carboxyl groups, could easily entrap either cationic drugs, in view of a possible controlled release, or poisonous metal cations, when they must be removed from blood. The second use can be made easier by the hemocompatibility, ascertained in preceding studies on other materials, synthesized by means of the reaction between maleic anhydride copolymers and hydroxyl-containing macromolecules. Another possible use is the production of ion exchanging gels, as fillers for both ion exchange and liquid chromatography columns, which could be easily regenerated. (literal)
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Autore CNR di
Prodotto
Insieme di parole chiave di
data.CNR.it