The lectin-like oxidized low-density lipoprotein receptor-1 and its soluble form: cardiovascular implications (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• The lectin-like oxidized low-density lipoprotein receptor-1 and its soluble form: cardiovascular implications (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.5551/jat.3228 (literal)

Alternative label

• Navarra T.; Del Turco S.; Berti S.; Basta G. (2010)
  The lectin-like oxidized low-density lipoprotein receptor-1 and its soluble form: cardiovascular implications
  in Journal of atherosclerosis and thrombosis (Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Navarra T.; Del Turco S.; Berti S.; Basta G. (literal)

Pagina inizio

• 317 (literal)

Pagina fine

• 331 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 17 (literal)

Rivista

• Journal of atherosclerosis and thrombosis (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• In: Journal of atherosclerosis and thrombosis, vol. 17 (4) pp. 317 - 331. J-stage, 2010. (literal)

Note

• ISI Web of Science (WOS) (literal)
• Scopus (literal)
• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR-IFC, Pisa, Fondazione G. Monasterio CNR-Regione Toscana, Massa, Italy (literal)

Titolo

• The lectin-like oxidized low-density lipoprotein receptor-1 and its soluble form: cardiovascular implications (literal)

Abstract

• The lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) is a multiligand receptor, whose repertoire of ligands includes oxidized low-density lipoprotein, advanced glycation endproducts, platelets, neutrophils, apoptotic/aged cells and bacteria. Sustained expression of LOX-1 by critical target cells, including endothelial cells, smooth muscle cells and macrophages in proximity to these ligands, sets the stage for chronic cellular activation and tissue damage suggesting the interaction of cellular LOX-1 with its ligands to contribute to the formation and development of atherosclerotic plaques. Studies with transgenic and knockout mouse models have elucidated in part the role of LOX-1 in the pathogenesis of atherosclerosis and cardiac remodeling. Recently, a circulating soluble form of LOX-1 (sLOX-1), corresponding solely to its extracellular domain, has been identified in human serum. Circulating levels of sLOX-1 are increased in inflammatory and atherosclerotic conditions and are associated with acute coronary syndrome, with the severity of coronary artery disease, and with serum biomarkers for oxidative stress and inflammation, suggesting that they could be a useful marker for vascular injury. However, many interesting questions have not yet been answered and in this review, we provide an updated overview of the literature on this receptor and on likely future directions. (literal)

Prodotto di

• MEDICINA TRASLAZIONALE (ME.P05.016.001) (Modulo)
• Istituto di fisiologia clinica (IFC) (Istituto)

Autore CNR

• SERENA DEL TURCO (Unità di personale interno)
• GIUSEPPINA BASTA (Persona)

Insieme di parole chiave

• Keywords of "The lectin-like oxidized low-density lipoprotein receptor-1 and its soluble form: cardiovascular implications" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di fisiologia clinica (IFC) (Istituto)
• MEDICINA TRASLAZIONALE (ME.P05.016.001) (Modulo)

Autore CNR di

• GIUSEPPINA BASTA (Persona)
• SERENA DEL TURCO (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of atherosclerosis and thrombosis (Rivista)

Insieme di parole chiave di

• Keywords of "The lectin-like oxidized low-density lipoprotein receptor-1 and its soluble form: cardiovascular implications" (Insieme di parole chiave)