Glutathione transferases as targets for cancer therapy (Articolo in rivista)

Type
Label
  • Glutathione transferases as targets for cancer therapy (Articolo in rivista) (literal)
Anno
  • 2009-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.2174/187152009789056895 (literal)
Alternative label
  • Paolo Ruzza; Antonio Rosato; Carlo Riccardo Rossi; Maura Floreani; Luigi Quintieri (2009)
    Glutathione transferases as targets for cancer therapy
    in Anti-cancer agents in medicinal chemistry (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Paolo Ruzza; Antonio Rosato; Carlo Riccardo Rossi; Maura Floreani; Luigi Quintieri (literal)
Pagina inizio
  • 763 (literal)
Pagina fine
  • 777 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 9 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 7 (literal)
Note
  • Scopu (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Institute of Biomolecular Chemistry of CNR, Padova Unit, Padova, Italy; Department of Oncology and Surgical Sciences, University of Padova, Italy; Istituto Oncologico Veneto, IOV, Padova, Italy; Department of Pharmacology and Anesthesiology, University of Padova, Italy (literal)
Titolo
  • Glutathione transferases as targets for cancer therapy (literal)
Abstract
  • Besides catalyzing the inactivation of various electrophile-producing anticancer agents via conjugation to the tripeptide glutathione, some cytosolic proteins belonging to the glutathione transferase (formerly glutatione-S-transferase; GST) superfamily are emerging as negative modulators of stress/drug-induced cell apoptosis through the interaction with specific signaling kinases. In addition, several data link the overexpression of some GSTs, in particular GSTP1-1, to both natural and acquired resistance to various structurally unrelated anticancer drugs. Tumor overexpression of these proteins has provided a rationale for the search of GST inhibitors and GSTactivated cytotoxic prodrugs. In the present review we discuss the current structural and pharmacological knowledge of both types of GST-targeting compounds. (literal)
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