Dynamic measure of gene co-regulation (Articolo in rivista)

Type
Label
  • Dynamic measure of gene co-regulation (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1049/iet-syb:20060031 (literal)
Alternative label
  • L Farina 1; A De Santis 1; G Morelli 2; I Ruberti 3 (2007)
    Dynamic measure of gene co-regulation
    in IET systems biology (Print); IET - The Institution of Engineering and Technology, Stevenage (Regno Unito)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • L Farina 1; A De Santis 1; G Morelli 2; I Ruberti 3 (literal)
Pagina inizio
  • 10 (literal)
Pagina fine
  • 17 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://digital-library.theiet.org/IET-SYB (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 1 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1 Dipartimento di Informatica e Sistemistica 'Antonio Ruberti', Universita` di Roma 'La Sapienza', Via Eudossiana 18, Rome 00184, Italy; 2 Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione, Rome, Italy; 3 Istituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche, Rome, Italy (literal)
Titolo
  • Dynamic measure of gene co-regulation (literal)
Abstract
  • Gene expression is to a large extent controlled at the level of mRNA accumulation. Genes whose products function together are likely under a common regulatory system ( e. g. signal transduction pathways, sets of regulatory proteins) such that they are expressed in a coordinated manner. This property has been frequently used in the analysis of genome-wide expression data, as the experimental observation that a group of genes is co-expressed frequently implies that the genes share a common regulatory mechanism. The authors have investigated the situation in which dissimilarity in gene-expression time profiles may still result from the presence of the same regulatory signal, as in the case of common transcription factors. To this aim, a dynamic model that takes into account the effect of specific mRNA degradation on the shape of gene-expression time series has been developed, and the concept of 'dynamically co-regulated' genes has accordingly been introduced as the goodness-of-fit to such a model ( called dynamic R 2). The statistical analysis of dynamic R 2 over a number of different experimental data sets and organisms shows that the presence of dynamically co-regulated genes is by far more significant than that expected from the randomised data. Furthermore, as an example of the usefulness of the proposed method, genome-wide yeast measurements such as cell-cycle time series and transcription factors targets data, were used to prove that dynamic co-regulation is statistically related to the presence of common transcription factor(s). This latter property is very useful when trying to infer computational indications of co-regulation for not-yet annotated genes that do not display a co-expression pattern. (literal)
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