Patients with oral erosive and cutaneous lichen planus may have antibodies directed against the chronic ulcerative stomatitis protein antigen of 70-kDa. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Patients with oral erosive and cutaneous lichen planus may have antibodies directed against the chronic ulcerative stomatitis protein antigen of 70-kDa. (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Alternative label

• Cozzani E. 1, Cacciapuoti M. 1, di Marco E. 2, Zerega B. 3, Descalzi Cancedda F. 4, Parodi A. 5 (2008)
  Patients with oral erosive and cutaneous lichen planus may have antibodies directed against the chronic ulcerative stomatitis protein antigen of 70-kDa.
  
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Cozzani E. 1, Cacciapuoti M. 1, di Marco E. 2, Zerega B. 3, Descalzi Cancedda F. 4, Parodi A. 5 (literal)

Pagina inizio

• 120 (literal)

Pagina fine

• 124 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 17 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Department of Endocrinological and Medical Sciences, Section of Dermatology, University of Genoa, Genova 2. Laboratorio di analisi Istituto Giannina Gaslini, Genova 3. Istituto Nazionale per la Ricerca sul Cancro/Centro Biotecnologie Avanzate, Genova 4. CNR-IBFM, Section of Genova, Genova 5. Department of Endocrinological and Medical Sciences, Section of Dermatology, University of Genoa, Genova (literal)

Titolo

• Patients with oral erosive and cutaneous lichen planus may have antibodies directed against the chronic ulcerative stomatitis protein antigen of 70-kDa. (literal)

Abstract

• OBJECTIVE: The aim of this study is to verify whether stratified epithelium-specific antinuclear antibodies are present in the sera of patients with erosive oral lichen planus and cutaneous lichen planus. METHODS: We studied the pre-immune and immune serum of a rabbit immunized with a peptide corresponding to the N-terminus of the 70-kDa antigen chronic ulcerative stomatitis protein; sera from two patients, one with oral erosive lichen planus and one with cutaneous lichen planus who presented stratified epithelium-specific antinuclear antibodies at high titer; and a third serum from a patient with cutaneous lichen planus without stratified epithelium-specific antinuclear antibodies. RESULTS: We demonstrated that the protein bands recognized by the serum of the rabbit immunized with an epitope of chronic ulcerative stomatitis protein co-migrated by SDS-PAGE with the protein bands recognized by the serum of a patient affected by oral erosive lichen planus and by the serum of a patient with cutaneous lichen planus, both containing antibodies directed against a 70-kDa antigen. CONCLUSIONS: Our results confirm that antibodies specifically directed against the chronic ulcerative stomatitis protein are not a distinctive marker of chronic ulcerative stomatitis, but may also be detected in oral erosive and cutaneous lichen planus (literal)

Prodotto di

• Genomica e proteomica per la ricerca di biomarcatori in malattie neurodegenerative e nei tumori (ME.P05.002.001) (Modulo)
• Institute of molecular bioimaging and physiology (IBFM) (Istituto)

Autore CNR

• FIORELLA DESCALZI (Unità di personale interno)

Incoming links:

Autore CNR di

• FIORELLA DESCALZI (Unità di personale interno)

Prodotto

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)
• Genomica e proteomica per la ricerca di biomarcatori in malattie neurodegenerative e nei tumori (ME.P05.002.001) (Modulo)