Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Alternative label

• D'Amelio M. 1,2, Cavallucci V. 1, Middei S. 3, Marchetti C. 4, Pacioni S. 5, Ferri A. 6, Diamantini A. 7, De Zio D.8, Carrara P.9, Battistini L.7, Moreno S.9, Bacci A.5, Ammassari-Teule M.3, Marie H.4, Cecconi F.1,8 (2011)
  Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease
  in Nature neuroscience (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• D'Amelio M. 1,2, Cavallucci V. 1, Middei S. 3, Marchetti C. 4, Pacioni S. 5, Ferri A. 6, Diamantini A. 7, De Zio D.8, Carrara P.9, Battistini L.7, Moreno S.9, Bacci A.5, Ammassari-Teule M.3, Marie H.4, Cecconi F.1,8 (literal)

Pagina inizio

• 69 (literal)

Pagina fine

• 76 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Epub 2010 Dec 12. (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 14(1) (literal)

Rivista

• Nature neuroscience (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• (*) L'Unità Operativa di Servizio dell'Istituto di Neuroscienze di Roma è stata soppressa il 12/1/2011 con provvedimento prot. n. 0002130 ed è confluita nell'IBCN, costituito il 21/12/2010 con provvedimento prot. n. 0091899. (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 - Dulbecco Telethon Institute at the Laboratory of Molecular Neuroembryology, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Fondazione Santa Lucia, Rome, Italy; 2 - Laboratory of Molecular Neuroscience, University Campus-Biomedico, Rome, Italy; 3 - Consiglio Nazionale delle Ricerche (CNR) Institute of Neuroscience, IRCCS Fondazione Santa Lucia, Rome, Italy(*); 4 - Laboratory of Molecular Mechanisms of Synaptic Plasticity, European Brain Research Institute, Rome, Italy; 5 - Laboratory of Cellular Physiology of Cortical Microcircuits, European Brain Research Institute, Rome, Italy; 6 - CNR Institute of Neuroscience, Department of Psychobiology and Psychopharmacology, Rome, Italy;(*) 7 - Laboratory of Neuroimmunology, IRCCS Fondazione Santa Lucia, Rome, Italy; 8 - Department of Biology, University of Rome 'Tor Vergata', Rome, Italy; 9 - Department of Biology-Interdepartmental Laboratory of Electron Microscopy (LIME), University Roma Tre, Rome, Italy. (*) Confluito in IBCN (provv. n. 116 del 21.12.2010 prot. 91899) (literal)

Titolo

• Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease (literal)

Abstract

• Synaptic loss is the best pathological correlate of the cognitive decline in Alzheimer's disease; however, the molecular mechanisms underlying synaptic failure are unknown. We found a non-apoptotic baseline caspase-3 activity in hippocampal dendritic spines and an enhancement of this activity at the onset of memory decline in the Tg2576-APPswe mouse model of Alzheimer's disease. In spines, caspase-3 activated calcineurin, which in turn triggered dephosphorylation and removal of the GluR1 subunit of AMPA-type receptor from postsynaptic sites. These molecular modifications led to alterations of glutamatergic synaptic transmission and plasticity and correlated with spine degeneration and a deficit in hippocampal-dependent memory. Notably, pharmacological inhibition of caspase-3 activity in Tg2576 mice rescued the observed Alzheimer-like phenotypes. Our results identify a previously unknown caspase-3-dependent mechanism that drives synaptic failure and contributes to cognitive dysfunction in Alzheimer's disease. These findings indicate that caspase-3 is a potential target for pharmacological therapy during early disease stages. (literal)

Prodotto di

• ex SV.P16.003.002 / Studio dei meccanismi molecolari di processi neurodegenerativi (SV.P16.003.005) (Modulo)
• ex ME.P05.007.001 / Modelli animali per lo studio del sistema nervoso (ME.P05.007.002) (Modulo)

Autore CNR

• ANNE MARIE TEULE (Persona)
• SILVIA MIDDEI (Persona)
• ALBERTO FERRI (Unità di personale interno)

Incoming links:

Autore CNR di

• ANNE MARIE TEULE (Persona)
• ALBERTO FERRI (Unità di personale interno)
• SILVIA MIDDEI (Persona)

Prodotto

• ex SV.P16.003.002 / Studio dei meccanismi molecolari di processi neurodegenerativi (SV.P16.003.005) (Modulo)
• ex ME.P05.007.001 / Modelli animali per lo studio del sistema nervoso (ME.P05.007.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Nature neuroscience (Rivista)