Reducing the risk of overdiagnosis in lung cancer: a support from molecular biology (Articolo in rivista)

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  • Reducing the risk of overdiagnosis in lung cancer: a support from molecular biology (Articolo in rivista) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1002/jcp.22558 (literal)
Alternative label
  • Barba Maddalena 1; Felsani Armando 2, Rinaldi Massimo 3, Giunta Salvatore 4, Malorni Walter 5, 6, Paggi Marco G.7 (2011)
    Reducing the risk of overdiagnosis in lung cancer: a support from molecular biology
    in Journal of cellular physiology (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Barba Maddalena 1; Felsani Armando 2, Rinaldi Massimo 3, Giunta Salvatore 4, Malorni Walter 5, 6, Paggi Marco G.7 (literal)
Pagina inizio
  • 2213 (literal)
Pagina fine
  • 3324 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • doi: 10.1002/jcp.22558 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 226 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • (*) L'INMM è stato soppresso il 12/1/2011 con provvedimento prot. n. 0002122 ed è confluito nell'IBCN costituito il 21/12/2010 con provvedimento prot. n. 0091899. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 9 (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • PubMed (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1 - Epidemiology, National Cancer Institute \"Regina Elena\", Rome, Italy 2 - CNR, Istituto di Neurobiologia e Medicina Molecolare, Rome, Italy (*); 3 - Medical Oncology Division B, National Cancer Institute \"Regina Elena\", Rome, Italy; 4 - Department of Radiology, National Cancer Institute \"Regina Elena\", Rome, Italy; 5 - Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanità, Rome, Italy; 6 - Istituto San Raffaele Sulmona, Sulmona (AQ), Italy; 7 - Department of Development of Therapeutic Programs, National Cancer Institute \"Regina Elena\", Rome, Italy. (literal)
Titolo
  • Reducing the risk of overdiagnosis in lung cancer: a support from molecular biology (literal)
Abstract
  • Early detection and swift treatment, when achievable, may significantly affect prognosis in lung cancer patients. Therefore, individuals with a high risk for lung cancer are invited to participate into international screening programs, such as the International Early Lung Cancer Action Program (I-ELCAP). An undesirable consequence of such massive enterprises is the detection of pulmonary nodules also in subjects who are unlikely to ultimately die from lung cancer. Nevertheless, the individuals with pulmonary nodule undergo stringent diagnostic procedures to assess the nature of the lesion. This implies a noticeable (physical and emotional) stress for our patients and the likelihood of overdiagnosis and, potentially, consequent overtreatment. Molecular markers, more specifically, microRNAs, might significantly add value to the workup process aiming at the distinction between benign and malignant lesions and, among the malignant ones, those concretely threatening for the patients' survival. We are confident that such a multidisciplinary approach would better suit our patients' diagnostic and/or therapeutic, actual needs. (literal)
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