http://www.cnr.it/ontology/cnr/individuo/prodotto/ID59268

Spine growth in the anterior cingulate cortex is necessary for the consolidation of contextual fear memory (Articolo in rivista)

Type

Label

Spine growth in the anterior cingulate cortex is necessary for the consolidation of contextual fear memory (Articolo in rivista) (literal)

Anno

Alternative label

Vetere G.1,2, Restivo L.1, Cole C. J.1, 3, Ross P. J.1, Ammassari-Teule M.2,4, Josselyn S. A.1,3,5, Frankland P.W. 1,3,5 (2011)
Spine growth in the anterior cingulate cortex is necessary for the consolidation of contextual fear memory
in Proceedings of the National Academy of Sciences of the United States of America
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Vetere G.1,2, Restivo L.1, Cole C. J.1, 3, Ross P. J.1, Ammassari-Teule M.2,4, Josselyn S. A.1,3,5, Frankland P.W. 1,3,5 (literal)

Pagina inizio

Pagina fine

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

Rivista

Note

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

1 - Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON, Canada M5G 1X8. 2 - Istituto di Ricerca a Carattere Clinico e Scientifico Fondazione Santa Lucia, 00143 Rome, Italy. 3 - Department of Physiology and eInstitute of Medical Science, University of Toronto, Toronto, ON, Canada M5S 1A8. 4 - Cell Biology and Neurobiology Institute, National Research Council, 00143 Rome, Italy. 5 - Institute of Medical Science, University of Toronto, Toronto, ON, Canada M5S 1A8. (literal)

Titolo

Spine growth in the anterior cingulate cortex is necessary for the consolidation of contextual fear memory (literal)

Abstract

Remodeling of cortical connectivity is thought to allow initially hippocampus-dependent memories to be expressed independently of the hippocampus at remote time points. Consistent with this, consolidation of a contextual fear memory is associated with dendritic spine growth in neurons of the anterior cingulate cortex (aCC). To directly test whether such cortical structural remodeling is necessary for memory consolidation, we disrupted spine growth in the aCC at different times following contextual fear conditioning in mice. We took advantage of previous studies showing that the transcription factor myocyte enhancer factor 2 (MEF2) negatively regulates spinogenesis both in vitro and in vivo. We found that increasing MEF2-dependent transcription in the aCC during a critical posttraining window (but not at later time points) blocked both the consolidation-associated dendritic spine growth and subsequent memory expression. Together, these data strengthen the causal link between cortical structural remodeling and memory consolidation and, further, identify MEF2 as a key regulator of these processes. (literal)

Prodotto di