Multifunctional Nanobeads Based on Quantum Dots and Magnetic Nanoparticles: Synthesis and Cancer Cell Targeting and Sorting (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Multifunctional Nanobeads Based on Quantum Dots and Magnetic Nanoparticles: Synthesis and Cancer Cell Targeting and Sorting (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Alternative label

• Di Corato R., N.C. Bigall, A. Ragusa, D. Dorfs, A. Genovese, R. Marotta, L. Manna and T. Pellegrino (2011)
  Multifunctional Nanobeads Based on Quantum Dots and Magnetic Nanoparticles: Synthesis and Cancer Cell Targeting and Sorting
  in ACS nano
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Di Corato R., N.C. Bigall, A. Ragusa, D. Dorfs, A. Genovese, R. Marotta, L. Manna and T. Pellegrino (literal)

Pagina inizio

• 1109 (literal)

Pagina fine

• 1121 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 5 (literal)

Rivista

• ACS nano (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• DOI: 10.1021/nn102761t Acknowledgment: This work was supported in part by the European project Magnifyco (Contract NMP4-SL-2009-228622). We thank Mario Malerba for TEM sample preparation and Rosanna Mastria and Angela Fiore for QD sample preparation. (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. CNR, Nanosci Inst, Natl Nanotechnol Lab, I-73100 Lecce, Italy (R. Di Corato, A. Ragusa, T. Pellegrino) 2. IIT, I-16163 Genoa, Italy(Di Corato, R (Di Corato, Riccardo)1,2; Bigall, NC (Bigall, Nadja C.)2; Ragusa, A (Ragusa, Andrea)1,2; Dorfs, D (Dorfs, Dirk)2; Genovese, A (Genovese, Alessandro)2; Marotta, R (Marotta, Roberto)2; Manna, L (Manna, Liberato)2; Pellegrino, T (Pellegrino, Teresa)1,2 (literal)

Titolo

• Multifunctional Nanobeads Based on Quantum Dots and Magnetic Nanoparticles: Synthesis and Cancer Cell Targeting and Sorting (literal)

Abstract

• Trifunctional polymer nanobeads are prepared by destabilization of a mixture of magnetic nanoparticles, quantum dots, and an amphiphilic polymer, followed by functionalization of the bead surface with folic acid molecules. The distribution of the nanoparticles within the nanobeads can be tuned using either acetonitrile or water as destabilizing solvent. The luminescence of the resulting beads can be tuned by varying the ratio of quantum dots per magnetic nanoparticles. The application of an external magnetic field (such as a small static magnet of 0.3 T) to the magnetic-fluorescent nanobeads allows the quantitative accumulation of the beads within a few hours depending on the total size of the beads. Furthermore, specific targeting of cancer cells overexpressing folate receptors is achieved thanks to the folic acid decorating the surface of the as-synthesized nanobeads. Folate receptor mediated cellular uptake of the folic acid-functionalized nanobeads is proven via both confocal imaging and transmission electron microscopy characterization. Cell sorting experiments performed with trifunctional nanobeads show quantitative recovering of targeted cells even when they are present at low percentage (up to 1%). (literal)

Prodotto di

• Nanocompositi (MD.P06.015.002) (Modulo)

Autore CNR

• TERESA PELLEGRINO (Persona)
• RICCARDO DI CORATO (Unità di personale esterno)

Insieme di parole chiave

• Keywords of "Multifunctional Nanobeads Based on Quantum Dots and Magnetic Nanoparticles: Synthesis and Cancer Cell Targeting and Sorting" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• TERESA PELLEGRINO (Persona)
• RICCARDO DI CORATO (Unità di personale esterno)

Prodotto

• Nanocompositi (MD.P06.015.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• ACS nano (Rivista)

Insieme di parole chiave di

• Keywords of "Multifunctional Nanobeads Based on Quantum Dots and Magnetic Nanoparticles: Synthesis and Cancer Cell Targeting and Sorting" (Insieme di parole chiave)