Acidic pH-Responsive Nanogels as Smart Cargo Systems for the Simultaneous Loading and Release of Short Oligonucleotides and Magnetic Nanoparticles (Articolo in rivista)

Type
Label
  • Acidic pH-Responsive Nanogels as Smart Cargo Systems for the Simultaneous Loading and Release of Short Oligonucleotides and Magnetic Nanoparticles (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Alternative label
  • Deka S.R., Quarta A., Di Corato R., Falqui A., Manna L., Cingolani R. and Pellegrino T. (2010)
    Acidic pH-Responsive Nanogels as Smart Cargo Systems for the Simultaneous Loading and Release of Short Oligonucleotides and Magnetic Nanoparticles
    in Langmuir
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Deka S.R., Quarta A., Di Corato R., Falqui A., Manna L., Cingolani R. and Pellegrino T. (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1. Ist Italian Tecnol, I-16163 Genoa, Italy 2. INFM, CNR, Nat Nanotechnol Lab, I-73100 Lecce, Italy 3. IIT Res Unit, I-73100 Lecce, Italy (literal)
Titolo
  • Acidic pH-Responsive Nanogels as Smart Cargo Systems for the Simultaneous Loading and Release of Short Oligonucleotides and Magnetic Nanoparticles (literal)
Abstract
  • Smart materials able to sense environmental stimuli can be exploited as intelligent carrier systems. Acidic pHresponsive polymers, for instance, exhibit a variation in the ionization state upon lowering the pH, which leads to their swelling. The different permeability of these polymers as a function of the pH could be exploited for the incorporation and subsequent release of previously trapped payload molecules/nanoparticles. We provide here a proof of concept of a novel use of pH-responsive polymer nanostructures based on 2-vinylpyridine and divinylbenzene, having an overall size below 200 nm, as cargo system for magnetic nanoparticles, for oligonucleotide sequences, as well as for their simultaneous loading and controlled release mediated by the pH. (literal)
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Autore CNR

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