http://www.cnr.it/ontology/cnr/individuo/prodotto/ID56895
Plant virus-mediated induction of miR168 is associated with repression of ARGONAUTE1 accumulation (Articolo in rivista)
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- Plant virus-mediated induction of miR168 is associated with repression of ARGONAUTE1 accumulation (Articolo in rivista) (literal)
- Anno
- 2010-01-01T00:00:00+01:00 (literal)
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Varallyay E.1, Valoczi A.1, Agyi A.1, Burgyan J.1,2 and Havelda Z.1 (2010)
Plant virus-mediated induction of miR168 is associated with repression of ARGONAUTE1 accumulation
in EMBO journal (Print)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Varallyay E.1, Valoczi A.1, Agyi A.1, Burgyan J.1,2 and Havelda Z.1 (literal)
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- Virus infections induce the expression of ARGONAUTE1
(AGO1) mRNA and in parallel enhance the accumulation
of miR168 (regulator of AGO1 mRNA). Here, we show that
in virus-infected plants the enhanced expression of AGO1
mRNA is not accompanied by increased AGO1 protein
accumulation. We also show that the induction of AGO1
mRNA level is a part of the host defence reaction, whereas
the induction of miR168, which overlaps spatially with
virus-occupied sectors, is mediated mainly by the
Tombusvirus p19 RNA-silencing suppressor. The absence
of p19 results in the elimination of miR168 induction and
accompanied with the enhanced accumulation of AGO1
protein. In transient expression study, p19 mediates the
induction of miR168 and the down-regulation of endogenous
AGO1 level. P19 is not able to efficiently bind
miR168 in virus-infected plants, indicating that this activity
is uncoupled from the small RNA-binding capacity of
p19. Our results imply that plant viruses can inhibit the
translational capacity of AGO1 mRNA by modulating
the endogenous miR168 level to alleviate the anti-viral
function of AGO1 protein.
(literal)
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- 1Agricultural Biotechnology Center, Godollo, Hungary,
2Instituto di Virologia Vegetale, Torino, Italy
(literal)
- Titolo
- Plant virus-mediated induction of miR168 is associated with repression of ARGONAUTE1 accumulation (literal)
- Abstract
- Virus infections induce the expression of ARGONAUTE1
(AGO1) mRNA and in parallel enhance the accumulation
of miR168 (regulator of AGO1 mRNA). Here, we show that
in virus-infected plants the enhanced expression of AGO1
mRNA is not accompanied by increased AGO1 protein
accumulation. We also show that the induction of AGO1
mRNA level is a part of the host defence reaction, whereas
the induction of miR168, which overlaps spatially with
virus-occupied sectors, is mediated mainly by the
Tombusvirus p19 RNA-silencing suppressor. The absence
of p19 results in the elimination of miR168 induction and
accompanied with the enhanced accumulation of AGO1
protein. In transient expression study, p19 mediates the
induction of miR168 and the down-regulation of endogenous
AGO1 level. P19 is not able to efficiently bind
miR168 in virus-infected plants, indicating that this activity
is uncoupled from the small RNA-binding capacity of
p19. Our results imply that plant viruses can inhibit the
translational capacity of AGO1 mRNA by modulating
the endogenous miR168 level to alleviate the anti-viral
function of AGO1 protein.
(literal)
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