http://www.cnr.it/ontology/cnr/individuo/prodotto/ID56692
Cucumber mosaic virus as carrier of a hepatitis C virus-derived epitope (Articolo in rivista)
- Type
- Label
- Cucumber mosaic virus as carrier of a hepatitis C virus-derived epitope (Articolo in rivista) (literal)
- Anno
- 2004-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1007/s00705-003-0190-x (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Natilla A.; Piazzola G.; Nuzzaci M.; Saldarelli P.; Tortorella C.; Intonaci S.; Piazzola P (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
- Impact factor 2004: 1.841 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
- Il lavoro descrive lo sviluppo di un vettore CMV come carrier di un epitopo per il virus dellepatite C (literal)
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- AFFILIAZIONE AUTORI: Dipartimento di Biologia, Difesa e Biotecnologie Agro-Forestali, Università Degli Studi della Basilicata, Potenza, Italy, IT; Dipartimento di Clinica Medica, Immunologia e Malattie Infettive, Università Degli Studi di Bari, Bari, Italy (literal)
- Titolo
- Cucumber mosaic virus as carrier of a hepatitis C virus-derived epitope (literal)
- Abstract
- ABSTRACT: Cucumber mosaic virus (CMV) is a three component isodiametric plant virus which is common worldwide and has an extremely wide host range. A pseudorecombinant was made, derived from the RNA3 component of the CMV-S strain, carrying the coat protein (CP) gene, and the RNA1,2 components of the CMV-D strain. This system developed mild mosaic and vein clearing in Xanthi tobacco three weeks after inoculation. The CP gene was then engineered in three different positions, to encode a Hepatitis C virus (HCV) epitope. The selected peptide was the so-called R9 mimotope, a synthetic surrogate derived from a consensus profile of many hypervariable region 1 (HVR1) sequences of the putative HCV envelope protein E2. Serum samples from 60 patients with chronic hepatitis C displayed a significant immunoreactivity to crude plant extracts infected with the chimeric CMV. These results suggest that further investigation should be made into a possible vaccine function for the CMV-HCV mimotope system. (literal)
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