Antinociceptive activity of Delta9-tetrahydrocannabinol non-ionic microemulsions. (Articolo in rivista)

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Label
  • Antinociceptive activity of Delta9-tetrahydrocannabinol non-ionic microemulsions. (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.ijpharm.2010.04.010 (literal)
Alternative label
  • Lazzari P a,b; Fadda P a,b; Marchese G a,b; Casu GL a,b; Pani L a,b (2010)
    Antinociceptive activity of Delta9-tetrahydrocannabinol non-ionic microemulsions.
    in International journal of pharmaceutics (Print); ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, AMSTERDAM (Paesi Bassi)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Lazzari P a,b; Fadda P a,b; Marchese G a,b; Casu GL a,b; Pani L a,b (literal)
Pagina inizio
  • 238 (literal)
Pagina fine
  • 243 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.elsevier.com/locate/ijpharm (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 393 (literal)
Rivista
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  • 6 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 1-2 (literal)
Note
  • PubMe (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • a Neuroscienze PharmaNess S.c.a r.l., c/o Sardegna Ricerche, Edificio 5, Località Piscinamanna, 09010 Pula (Cagliari), Italy; b Consiglio Nazionale delle Ricerche, Istituto di Tecnologie Biomediche - sezione di Cagliari, (literal)
Titolo
  • Antinociceptive activity of Delta9-tetrahydrocannabinol non-ionic microemulsions. (literal)
Abstract
  • Delta(9)-Tetrahydrocannabinol (Delta(9)-THC), the major psychoactive constituent of Cannabis sativa L., has been widely studied for its potential pharmaceutical application in the treatment of various diseases and disturbs. This sparingly soluble terpeno-phenolic compound is not easy to handle and to be formulated in pharmaceutical preparations. The aim of this work was to develop a stable aqueous Delta(9)-THC formulation acceptable for different ways of administration, and to evaluate the therapeutic properties of the new Delta(9)-THC based preparation for pain treatment. Due to the thermodynamic stability and advantages of microemulsion based systems, the study was focused on the identification of aqueous microemulsion based systems containing Delta(9)-THC. Oil in water Delta(9)-THC microemulsions were individuated through phase diagrams construction, using the non-ionic surfactant Solutol HS15, being this surfactant acceptable for parenteral administration in human. A selected microemulsion samples containing 0.2 wt% of Delta(9)-THC, stable up to 52 degrees C, was successfully assayed on animal models of pain. Significant antinociceptive activity has been detected by both intraperitoneal and intragastric administration of the new Delta(9)-THC pharmaceutical preparation. The effect has been highlighted in shorter time if compared to a preparation of the same active principle based on previously reported conventional preparation. (literal)
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