The Mammary Gland and the Homeobox Gene Otx1 (Articolo in rivista)

Type
Label
  • The Mammary Gland and the Homeobox Gene Otx1 (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Alternative label
  • Pagani IS, Terrinoni A, Marenghi L, Zucchi I, Chiaravalli AM, Serra V, Rovera F, Sirchia S, Dionigi G, Mozzo M, Frattini A, Ferrari A, Capella C, Pasquali F, Curto FL, Albertini A, Melino G, Porta G. (2010)
    The Mammary Gland and the Homeobox Gene Otx1
    in The breast journal
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Pagani IS, Terrinoni A, Marenghi L, Zucchi I, Chiaravalli AM, Serra V, Rovera F, Sirchia S, Dionigi G, Mozzo M, Frattini A, Ferrari A, Capella C, Pasquali F, Curto FL, Albertini A, Melino G, Porta G. (literal)
Pagina inizio
  • s53 (literal)
Pagina fine
  • s56 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 16(1) (literal)
Rivista
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  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Ilaria S. Pagani, Department of Experimental and Clinical Biomedical Sciences, University of Insubria, Varese, Italy Alessandro Terrinoni Biochemistry Laboratory, IDI-IRCCS, C/O Department of Experimental Medicine and Biochemical Sciences, University of Rome “Tor Vergata”, Rome, Italy Laura Marenghi, Department of Experimental and Clinical Biomedical Sciences, University of Insubria, Varese, Italy Ileana Zucchi, Institute of Biomedical Technologies, National Research Council, Milan, Italy Anna M. Chiaravalli, Department of Pathology, Ospedale di Circolo, Varese, Italy Valeria Serra, Biochemistry Laboratory, IDI-IRCCS, C/O Department of Experimental Medicine and Biochemical Sciences, University of Rome “Tor Vergata”, Rome, Italy Francesca Rovera, Department of Surgical Sciences, University of Insubria, Varese, Italy Silvia Sirchia, Department of Medicine, Surgery and Dentistry, Medical Genetics Unit, Universita` degli Studi di Milano, Milano, Italy Gianlorenzo Dionigi, Endocrine Surgery Research Center, Department of Surgical Sciences, University of Insubria, Varese, Italy Monica Mozzo, Endocrine Surgery Research Center, Department of Surgical Sciences, University of Insubria, Varese, Italy Annalisa Frattini, Institute of Biomedical Technologies, National Research Council, Milan, Italy Alberta Ferrari, Fondazione I.R.C.C.S. Policlinico San Matteo, Pavia, Italy Carlo Capella, Department of Human Morphology, Anatomic Pathology Unit, Centro Insubre di Biotecnologie per la Salute Umana, Ospedale di Circolo, University of Insubria, Varese, Italy Francesco Pasquali, Department of Experimental and Clinical Biomedical Sciences, University of Insubria, Varese, Italy Francesco L. Curto , Department of Experimental and Clinical Biomedical Sciences, University of Insubria, Varese, Italy Alberto Albertini, Institute of Biomedical Technologies, National Research Council, Milan, Italy Gerry Melino, Medical Research Council, Toxicology Unit, Leicester University, Leicester, United Kingdom Giovanni Porta Department of Experimental and Clinical Biomedical Sciences, University of Insubria, Varese, Italy (literal)
Titolo
  • The Mammary Gland and the Homeobox Gene Otx1 (literal)
Abstract
  • The mammary gland, the unique organ that primarily form at puberty, is an ideal model to study the functions of homeobox (HB) genes in both development and tumorigenesis. HB genes comprise a large family of developmental regulators that have a critical role in cell growth and differentiation. In the normal mammary gland, homeobox genes are involved in ductal formation, epithelial branching, and lobulo-alveolar development by regulating epithelial proliferation and differentiation. The HB genes are controlled in a spatial and temporal manner in both stromal and epithelial cells. They are coordinately regulated by hormones and extracellular matrix, suggesting that many signaling pathways are involved in homeobox gene functions. When homeobox genes are misexpressed in animal models, different defects are displayed in mammary gland development. Aberrant expression of homeobox genes, overexpressed or downregulated, is found in primary carcinomas and in breast cancer. The Otx1 HB gene is a classic regulatory of nervous system development during embryogenesis. Postnatally Otx1 is transcribed in the anterior pituitary gland, where activates transcription of the pituitary hormones, and plays a role in hematopoiesis, enhancing pluripotent cells, and erythroid differentiation. Otx1 can still be detected in mature cells of the erythroid and megacaryocytic lineage. During cyclical development of mammary gland, the Otx1 gene is overexpressed in lactation, confirming a role of this transcription factor in cell differentiation. Recent studies report that Otx1 is overexpressed in breast cancer. Otx1 is expressed during embryogenesis, and it is expressed again during carcinogenesis, implying its possible function in differentiation of neoplastic cells. (literal)
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