The expanding universe of cohesin functions: a new genome stability caretaker involved in human disease and cancer (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• The expanding universe of cohesin functions: a new genome stability caretaker involved in human disease and cancer (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1002/humu.21252 (literal)

Alternative label

• Mannini L, Menga S, Musio A (2010)
  The expanding universe of cohesin functions: a new genome stability caretaker involved in human disease and cancer
  in Human mutation
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Mannini L, Menga S, Musio A (literal)

Pagina inizio

• 623 (literal)

Pagina fine

• 630 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 31 (literal)

Rivista

• Human mutation (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Istituto di Ricerca Genetica e Biomedica (literal)

Titolo

• The expanding universe of cohesin functions: a new genome stability caretaker involved in human disease and cancer (literal)

Abstract

• Cohesin is responsible for sister chromatid cohesion, ensuring the correct chromosome segregation. Beyond this role, cohesin and regulatory cohesin genes seem to play a role in preserving genome stability and gene transcription regulation. DNA damage is thought to be a major culprit for many human diseases, including cancer. Our present knowledge of the molecular basis underlying genome instability is extremely limited. Mutations in cohesin genes cause human diseases such as Cornelia de Lange syndrome and Roberts syndrome/SC phocomelia, and all the cell lines derived from affected patients show genome instability. Cohesin mutations have also been identified in colorectal cancer. Here, we will discuss the human disorders caused by alterations of cohesin function, with emphasis on the emerging role of cohesin as a genome stability caretaker (literal)

Autore CNR

• ANTONIO MUSIO (Persona)

Insieme di parole chiave

• Keywords of "The expanding universe of cohesin functions: a new genome stability caretaker involved in human disease and cancer" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ANTONIO MUSIO (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Human mutation (Rivista)

Prodotto

• http://www.cnr.it/ontology/cnr/individuo/modulo/ID6952

Insieme di parole chiave di

• Keywords of "The expanding universe of cohesin functions: a new genome stability caretaker involved in human disease and cancer" (Insieme di parole chiave)