Neuromelanin and iron in human locus coeruleus and substantia nigra during aging: consequences for neuronal vulnerability. (Articolo in rivista)

Type
Label
  • Neuromelanin and iron in human locus coeruleus and substantia nigra during aging: consequences for neuronal vulnerability. (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1007/s00702-006-0453-2 (literal)
Alternative label
  • Zucca F.A.; Bellei C.; Giannelli S.; Terreni M.R.; Gallorini M.; Rizzio E.; Pezzoli G.; Albertini A.; Zecca L. (2006)
    Neuromelanin and iron in human locus coeruleus and substantia nigra during aging: consequences for neuronal vulnerability.
    in Journal of neural transmission
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Zucca F.A.; Bellei C.; Giannelli S.; Terreni M.R.; Gallorini M.; Rizzio E.; Pezzoli G.; Albertini A.; Zecca L. (literal)
Pagina inizio
  • 757 (literal)
Pagina fine
  • 767 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 113 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 6 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Institute of Biomedical Technologies - C.N.R., Segrate (Milano); Department of Pathology, San Raphael Institute, Milano; Institute of Metrology ''G. Colonnetti'', C.N.R., Pavia; Parkinson's Institute, Milano, Italy. (literal)
Titolo
  • Neuromelanin and iron in human locus coeruleus and substantia nigra during aging: consequences for neuronal vulnerability. (literal)
Abstract
  • In this study a comparative analysis of iron molecules during aging was performed in locus coeruleus (LC) and substantia nigra (SN), known targets of Parkinson's Disease (PD) and related disorders. LC and SN neurons, especially the SN pars compacta, degenerate in PD and other forms of parkinsonism. Iron and its major molecular forms, such as ferritin and neuromelanin (NM), were measured in LC and SN of normal subjects at various ages. Iron levels were lower, H-ferritin/iron ratio was higher and the iron content in NM was lower in LC than in SN. Iron deposits were abundant in SN tissue, very scarse in LC tissue and completely absent in pigmented neurons of both SN and LC. In both regions H- and L-ferritins were present only in glia. This suggests that in LC neurons iron mobilization and toxicity is lower than that in SN and is efficiently buffered by NM. Ferritins accomplish the same buffering function in glial cells. (literal)
Prodotto di
Autore CNR

Incoming links:


Autore CNR di
Prodotto
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
data.CNR.it