A novel polymorphism in SEL1L confers susceptibility to Alzheimer's disease (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• A novel polymorphism in SEL1L confers susceptibility to Alzheimer's disease (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.neulet.2005.12.038 (literal)

Alternative label

• Saltini, G; Dominici, R; Lovati, C; Cattaneo, M; Michelini, S; Malferrari, G; Caprera, A; Milanesi, L; Finazzi, D; Bertora, P; Scarpini, E; Galimberti, D; Venturelli, E; Musicco, M; Adorni, F; Mariani, C; Biunno, I (2006)
  A novel polymorphism in SEL1L confers susceptibility to Alzheimer's disease
  in Neuroscience letters (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Saltini, G; Dominici, R; Lovati, C; Cattaneo, M; Michelini, S; Malferrari, G; Caprera, A; Milanesi, L; Finazzi, D; Bertora, P; Scarpini, E; Galimberti, D; Venturelli, E; Musicco, M; Adorni, F; Mariani, C; Biunno, I (literal)

Pagina inizio

• 53 (literal)

Pagina fine

• 58 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 398 (literal)

Rivista

• Neuroscience letters (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 6 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1-2 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Consiglio Nazionale delle Ricerche (CNR); University of Milan; University of Milan; Osped L Sacco; University of Milan; University of Milan; University of Brescia; BioRep SrL (literal)

Titolo

• A novel polymorphism in SEL1L confers susceptibility to Alzheimer's disease (literal)

Abstract

• Alzheimer's disease (AD) is considered to be a conformational disease arising from the accumulation of misfolded and unfolded proteins in the endoplasmic reticulum (ER). SEL1L is a component of the ER stress degradation system, which serves to remove unfolded proteins by retrograde degradation using the ubiquitin-proteosome system. In order to identify genetic variations possibly involved in the disease, we analysed the entire SEL1L gene sequence in Italian sporadic AD patients. Here we report on the identification of a new polymorphism within the SEL1L intron 3 (IVS3-88 A>G), which contains potential binding sites for transcription factors involved in ER-induced stress. Our statistical analysis shows a possible role of the novel polymorphism as independent susceptibility factor of Alzheimer's dementia. (C) 2005 Published by Elsevier Ireland Ltd. (literal)

Prodotto di

• Applicazioni della Bioinformatica e Neuroinformatica al GRID computing (PM.P06.010.001) (Modulo)
• Genomica e proteomica funzionale (PM.P06.010.003) (Modulo)

Autore CNR

• IDA BIUNNO (Unità di personale interno)
• MASSIMO MUSICCO (Persona)
• LUCIANO MILANESI (Persona)

Insieme di parole chiave

• Parole chiave di "A novel polymorphism in SEL1L confers susceptibility to Alzheimer's disease" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• MASSIMO MUSICCO (Persona)
• IDA BIUNNO (Unità di personale interno)
• LUCIANO MILANESI (Persona)

Prodotto

• Applicazioni della Bioinformatica e Neuroinformatica al GRID computing (PM.P06.010.001) (Modulo)
• Genomica e proteomica funzionale (PM.P06.010.003) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Neuroscience letters (Rivista)

Insieme di parole chiave di

• Parole chiave di "A novel polymorphism in SEL1L confers susceptibility to Alzheimer's disease" (Insieme di parole chiave)