IL-18 in autoimmunity (Articolo in rivista)

Type
Label
  • IL-18 in autoimmunity (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Alternative label
  • Boraschi D, Dinarello CA (2006)
    IL-18 in autoimmunity
    in European cytokine network (Montrouge)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Boraschi D, Dinarello CA (literal)
Pagina inizio
  • 224 (literal)
Pagina fine
  • 252 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 17 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 4 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Diana Boraschi: Laboratory of Cytokines, Unit of Immunobiology, Institute of Biomedical Technologies, National Research Council, CNR, Area della Ricerca di S. Cataldo, via G. Moruzzi 1, I-56124 Pisa, Italy Charles A. Dinarello: Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO 80262, USA (literal)
Titolo
  • IL-18 in autoimmunity (literal)
Abstract
  • IL-18 is among the cytokines responsible for immune-mediated pathologies and is probably one of the factors that contribute to the pathogenesis of autoimmune diseases. Identification of the causes of uncontrolled IL-18 production and activity in autoimmunity would allow for novel therapeutic targets to effectively block autoimmune activation and inhibit concomitant tissue damage. IL-18 is produced mainly by monocytes/macrophages in response to stimuli of viral/bacterial origin, its production being therefore one of the effects of innate immunity initiated by host-pathogen interaction. In this review, we summarise the evidence supporting both the effector and the pathogenic role of IL-18 in autoimmunity, and propose that the disturbed mechanism of innate immunity, resulting from macrophage activation through innate immunity receptors (TLR/IL-1R family), may be the basis of pathologically high levels of IL-18 production and activation. Unravelling the mechanisms of IL-18 production and activity in autoimmune diseases will allow the identification of targets for more effective therapeutic intervention. (literal)
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