Inhibition of BUB1 results in genomic instability and anchorage-independent growth of normal human fibroblasts. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Inhibition of BUB1 results in genomic instability and anchorage-independent growth of normal human fibroblasts. (Articolo in rivista) (literal)

Anno

• 2003-01-01T00:00:00+01:00 (literal)

Alternative label

• Musio A, Montagna C, Zambroni D, Indino E, Barbieri O, Citti L, Villa A, Ried T, Vezzoni P. (2003)
  Inhibition of BUB1 results in genomic instability and anchorage-independent growth of normal human fibroblasts.
  in Cancer research (Chic. Ill.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Musio A, Montagna C, Zambroni D, Indino E, Barbieri O, Citti L, Villa A, Ried T, Vezzoni P. (literal)

Pagina inizio

• 2855 (literal)

Pagina fine

• 2863 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 63 (literal)

Rivista

• Cancer research (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Titolo

• Inhibition of BUB1 results in genomic instability and anchorage-independent growth of normal human fibroblasts. (literal)

Abstract

• The relative contribution of aneuploidy and gene mutations to human tumorigenesis is not yet known. Studies in mice have demonstrated that even single point mutations in oncogenes and tumor suppressor genes can dramatically increase tumor frequency. However, models to evaluate the definitive role of aneuploidy and genomic instability are not yet available. Human fibroblast cells have long been used as a tool for investigating proliferation, senescence, immortalization, and tumorigenesis, all processes that are strongly interrelated. We have now used antisense and ribozyme-mediated temporary inhibition of BUB1 to study the consequences of mitotic checkpoint failure on the development of aneuploidy. The analysis of cell colonies selected by soft agar growth showed evidence of chromosome instability and delayed senescence, without being tumorigenic in nude mice. Our data suggest that chromosomal instability and aneuploidy are early changes that precede tumorigenicity in the multistep process leading to neoplastic transformation. (literal)

Prodotto di

• Modelli animali innovativi (SV.P16.004.001) (Modulo)
• Genomica Funzionale: individuazione delle basi molecolari di difetti delle cellule T e B e dell'osso (ME.P05.011.001) (Modulo)

Autore CNR

• PAOLO MARIA VEZZONI (Unità di personale interno)
• ANTONIO MUSIO (Persona)
• ANNA VILLA (Unità di personale interno)

Incoming links:

Autore CNR di

• ANNA VILLA (Unità di personale interno)
• ANTONIO MUSIO (Persona)
• PAOLO MARIA VEZZONI (Unità di personale interno)

Prodotto

• Modelli animali innovativi (SV.P16.004.001) (Modulo)
• Genomica Funzionale: individuazione delle basi molecolari di difetti delle cellule T e B e dell'osso (ME.P05.011.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Cancer research (Rivista)