Preparation of stimulus responsive multiple emulsions by membrane emulsification using con A as biochemical sensor (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Preparation of stimulus responsive multiple emulsions by membrane emulsification using con A as biochemical sensor (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1002/bit.22992 (literal)

Alternative label

• Piacentini E., Drioli E., Giorno L. (2011)
  Preparation of stimulus responsive multiple emulsions by membrane emulsification using con A as biochemical sensor
  in Biotechnology and bioengineering (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Piacentini E., Drioli E., Giorno L. (literal)

Pagina inizio

• 913 (literal)

Pagina fine

• 923 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 108 (literal)

Rivista

• Biotechnology and bioengineering (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute on Membrane Technology, CNR-ITM (literal)

Titolo

• Preparation of stimulus responsive multiple emulsions by membrane emulsification using con A as biochemical sensor (literal)

Abstract

• In this work, a novel strategy for the controlled fabrication of biomolecular stimulus responsive water-in-oilin- water (W/O/W) multiple emulsion using the membrane emulsification process was investigated. The emulsions interface was functionalized with a biomolecule able to function as a receptor for a target compound. The interaction between the biomolecular receptor and target stimulus activated the release of bioactive molecules contained within the structured emulsion. A glucose sensitive emulsion was investigated as a model study case. Concanavalin A (Con A) was used as the biomolecular glucose sensor. Various physicochemical strategies for stimulus responsive materials formulation are available in literature, but the preparation of biomolecule-responsive emulsions has been explored for the first time in this paper. The development of novel drug delivery systems requires advanced and highly precise techniques to obtain their particular properties and targeting requirements. The present study has proven the flexibility and suitability of membrane emulsification for the preparation of stable and functional multiple emulsions containing Con A as interfacial biomolecular receptor able to activate the release of a bioactive molecule as a consequence of interaction with the glucose target molecule. The influence of emulsion interfacial composition and membrane emulsification operating conditions on droplets stability and functional properties have been investigated. The release of the bioactive molecule as a function of glucose stimulus and its concentration has been demonstrated. (literal)

Prodotto di

• Operazioni a membrana in processi biotecnologici (PM.P02.008.002) (Modulo)
• Institute on membrane technology (ITM) (Istituto)

Autore CNR

• ENRICO DRIOLI (Unità di personale esterno)
• EMMA PIACENTINI (Unità di personale esterno)
• LIDIETTA GIORNO (Persona)

Insieme di parole chiave

• Parole chiave di "Preparation of stimulus responsive multiple emulsions by membrane emulsification using con A as biochemical sensor" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute on membrane technology (ITM) (Istituto)
• Operazioni a membrana in processi biotecnologici (PM.P02.008.002) (Modulo)

Autore CNR di

• LIDIETTA GIORNO (Persona)
• ENRICO DRIOLI (Unità di personale esterno)
• EMMA PIACENTINI (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Biotechnology and bioengineering (Rivista)

Insieme di parole chiave di

• Parole chiave di "Preparation of stimulus responsive multiple emulsions by membrane emulsification using con A as biochemical sensor" (Insieme di parole chiave)