Capillary Electrophoresis, ROESY NMR and Molecular Modelling Study of the Inclusion Complex Beta-Cyclodextrin/Lipoic acid (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Capillary Electrophoresis, ROESY NMR and Molecular Modelling Study of the Inclusion Complex Beta-Cyclodextrin/Lipoic acid (Articolo in rivista) (literal)

Anno

• 2002-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1002/1099-0690%28200204%292002:7%3C1191::AID-EJOC1191%3E3.0.CO;2-I (literal)

Alternative label

• Carofiglio T., Fornasier R., Jicsinszky L., Saielli G., Tonellato U., Vetta R. (2002)
  Capillary Electrophoresis, ROESY NMR and Molecular Modelling Study of the Inclusion Complex Beta-Cyclodextrin/Lipoic acid
  in European journal of organic chemistry (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Carofiglio T., Fornasier R., Jicsinszky L., Saielli G., Tonellato U., Vetta R. (literal)

Pagina inizio

• 1191 (literal)

Pagina fine

• 1196 (literal)

Rivista

• European journal of organic chemistry (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Univ Padua, Dipartimento Chim Inorgan Met Organ & Analit, I-35100 Padua, Italy Univ Padua, Dipartimento Chim Organ, CNR, I-35131 Padua, Italy CYCLOLAB, R&D Lab, H-1117 Budapest, Hungary Univ Padua, CNR, Ctr Meccanismi Reaz Organ, I-35131 Padua, Italy (literal)

Titolo

• Capillary Electrophoresis, ROESY NMR and Molecular Modelling Study of the Inclusion Complex Beta-Cyclodextrin/Lipoic acid (literal)

Abstract

• The interaction of lipoic acid with b-cyclodextrin (b-CD) has been studied by capillary electrophoresis in aqueous phosphate buffer (20 mM, pH = 9.0) at 20 °C. The results allowed us to detect the formation of an inclusion complex with a 1:1 lipoic acid/ b-CD stoichiometry and an association constant of 1645 M-1. The geometry of the inclusion complex in D2O was investigated by means of 2D-ROESY (Rotating-frame Overhauser Enhancement Spectroscopy) NMR experiments, which showed the occurrence of a bimodal complexation of lipoic acid inside the b-CD cavity. Semi-empirical calculations using the PM3 method show that the orientations of the included lipoic acid are very close in energy, thus confirming the experimental observations. (literal)

Prodotto di

• Institute on membrane technology (ITM) (Istituto)

Autore CNR

• GIACOMO SAIELLI (Persona)

Incoming links:

Prodotto

• Institute on membrane technology (ITM) (Istituto)

Autore CNR di

• GIACOMO SAIELLI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• European journal of organic chemistry (Rivista)