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Polymer-drug conjugates for combination anticancer therapy: investigating the mechanism of action (Articolo in rivista)

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Polymer-drug conjugates for combination anticancer therapy: investigating the mechanism of action (Articolo in rivista) (literal)

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Pasut G., Greco V., Mero A., Mendichi R., Fante C., Green R. J., Veronese F. M. (2009)
Polymer-drug conjugates for combination anticancer therapy: investigating the mechanism of action
in Journal of medicinal chemistry
(literal)

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Pasut G., Greco V., Mero A., Mendichi R., Fante C., Green R. J., Veronese F. M. (literal)

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Mendichi R.; Istituto per lo Studio delle Macromolecole (CNR), Milano, Italy Pasut G., Mero A., Veronese F. M.; University of Padova, Padova, Italy Greco V., Fante C., Green R. J.; University of Reading, Reading, U. K. (literal)

Titolo

Polymer-drug conjugates for combination anticancer therapy: investigating the mechanism of action (literal)

Abstract

We developed a family of polymer-drug conjugates carrying the combination of the anticancer agent epirubicin (EPI) and nitric oxide (NO). EPI-PEG-(NO)8, carrying the highest content of NO, displayed greater activity in Caco-2 cells while it decreased toxicity against endothelium cells and cardiomyocytes with respect to free EPI. FACS and confocal microscopy confirmed conjugates internalization. Light scattering showed formation of micelle whose size correlated with internalization rate. EPI-PEG-(NO)8 showed increased bioavailability in mice compared to free EPI (literal)

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