Identification and functional characterization of the bile acid transport proteins in non-mammalian ileum and mammalian liver (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Identification and functional characterization of the bile acid transport proteins in non-mammalian ileum and mammalian liver (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1002/prot.21518 (literal)

Alternative label

• Guariento M.; Raimondo D.; Assfalg M. ; Zanzoni S. ; Pesente P.; Ragona L. ; Tramontano A. ; Molinari H. (2008)
  Identification and functional characterization of the bile acid transport proteins in non-mammalian ileum and mammalian liver
  in Proteins (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Guariento M.; Raimondo D.; Assfalg M. ; Zanzoni S. ; Pesente P.; Ragona L. ; Tramontano A. ; Molinari H. (literal)

Pagina inizio

• 462 (literal)

Pagina fine

• 472 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 70 (literal)

Rivista

• Proteins (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 2 (literal)

Note

• ISI Web of Science (WOS) (literal)
• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Anna Tramontano, Univ Roma La Sapienza Laura Ragona, ISMAC CNR Henriette Molinari, Mara Guariento, Michael Assfalg , Serena Zanzoni Università di Verona, Department of Science and Technology Domenico Raimondo , Seconda Università di Napoli, Department of Life Sciences, Caserta Patrizia Pesente,Laboratorio Tre Valli, Corte Pellegrina, San Martino Buon Albergo, Verona (literal)

Titolo

• Identification and functional characterization of the bile acid transport proteins in non-mammalian ileum and mammalian liver (literal)

Abstract

• It has been proposed that intracellular carrier proteins mediate active transport of the bile acids within hepatocytes and ileocytes, during the enterohepatic circulation. In mammalian species only ileal bile acid binding proteins have been so far identified, while liver cytosolic carriers have never been found. On the contrary, in non-mammalian vertebrates, only liver, and not ileal, bile acid binding proteins were reported. The aim of the present work is to find the missing cytosolic transport proteins. A bioinformatic search allowed us to identify a non-mammalian putative bile acid binding protein in the chicken ileum (cI-BABP), which we recombinantly expressed and purified. The protein exhibits the capability, tested by in vitro NMR experiments, of binding bile acids. Furthermore, strong NMR evidence reported that the human liver fatty acid binding protein (hL-FABP) can also bind bile acids. Taken together, these data strongly suggest that both cI-BABP and hL-FABP have a bile acid binding function in the two organisms, and support a previous hypothesis on the role of hL-FABP in regulating bile acid metabolism and determining bile acid pool size. (literal)

Prodotto di

• Istituto per lo studio delle macromolecole (ISMAC) (Istituto)
• Strutturistica NMR di proteine legate a processi patologici (PM.P01.026.003) (Modulo)

Autore CNR

• LAURA GIUDITTA RAGONA (Persona)

Incoming links:

Prodotto

• Istituto per lo studio delle macromolecole (ISMAC) (Istituto)
• Strutturistica NMR di proteine legate a processi patologici (PM.P01.026.003) (Modulo)

Autore CNR di

• LAURA GIUDITTA RAGONA (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Proteins (Rivista)