Nanoparticles based on novel amphiphilic polyaspartamide copolymers (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Nanoparticles based on novel amphiphilic polyaspartamide copolymers (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Alternative label

• E.F. Craparo, G. Teresi, M.C. Ognibene, M.P. Casaletto, M.L. Bondì, G. Cavallaro (2010)
  Nanoparticles based on novel amphiphilic polyaspartamide copolymers
  in Journal of nanoparticle research
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• E.F. Craparo, G. Teresi, M.C. Ognibene, M.P. Casaletto, M.L. Bondì, G. Cavallaro (literal)

Pagina inizio

• 2629 (literal)

Pagina fine

• 2644 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 12 (literal)

Rivista

• Journal of nanoparticle research (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR-ISMN Dipartimento di Chimica e Tecnologie Farmaceutiche, Università di Palermo (literal)

Titolo

• Nanoparticles based on novel amphiphilic polyaspartamide copolymers (literal)

Abstract

• In this article, the synthesis of two amphiphilic polyaspartamide copolymers, useful to obtain polymeric nanoparticles without using surfactants or stabilizing agents, is described. These copolymers were obtained starting from a,b-poly-(N-2-hydroxyethyl)DL-aspartamide (PHEA) by following a novel synthetic strategy. In particular, PHEA and its pegylated derivative (PHEA-PEG) were functionalized with poly(lactic acid) (PLA) through carbonyldiimidazoleCDI) activation to obtain PHEA-PLA and PHEA-PEG-PLA graft copolymers, respectively. These copolymers were properly purified and characterized by 1H-NMR, FT-IR, and Size Exclusion Chromatography (SEC) analyses, which confirmedthat derivatization reactions occurred. Nanoparticles were obtained from PHEA-PLA and PHEA-PEGPLA graft copolymers by using the high pressure homogenization-solvent evaporation method, avoiding the use of surfactants or stabilizing agents. Polymeric nanoparticles were characterized by dimensional analysis, before and after freeze-drying process, and Scanning Electron Microscopy (SEM). Zeta potential measurements and X-ray Photoelectron Spectroscopy (XPS) analysis demonstrated the presence of PEG and/or PHEA onto the PHEA-PEG-PLA and PHEA-PLA nanoparticle surface, respectively. (literal)

Prodotto di

• Materiali e sistemi nanostrutturati per drug delivery e terapie medicali (PM.P05.004.010) (Modulo)
• Istituto per lo studio dei materiali nanostrutturati (ISMN) (Istituto)

Autore CNR

• MARIA LUISA BONDI' (Unità di personale interno)
• MARIA PIA CASALETTO (Unità di personale interno)

Incoming links:

Prodotto

• Istituto per lo studio dei materiali nanostrutturati (ISMN) (Istituto)
• Materiali e sistemi nanostrutturati per drug delivery e terapie medicali (PM.P05.004.010) (Modulo)

Autore CNR di

• MARIA PIA CASALETTO (Unità di personale interno)
• MARIA LUISA BONDI' (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of nanoparticle research (Rivista)