Nanoparticles of cationic amphiphilic cyclodextrins entangling anionic porphyrins as a carrioer sensitizer system in photodynamic cancer therapy (Articolo in rivista)

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Label
  • Nanoparticles of cationic amphiphilic cyclodextrins entangling anionic porphyrins as a carrioer sensitizer system in photodynamic cancer therapy (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.biomaterials.2006.03.035 (literal)
Alternative label
  • S.Sortino; A.Mazzaglia; L.Monsù Scolaro; F. Marino Merlo; V. Valveri; M.T. Sciortino (2006)
    Nanoparticles of cationic amphiphilic cyclodextrins entangling anionic porphyrins as a carrioer sensitizer system in photodynamic cancer therapy
    in Biomaterials; Elsevier Science Ltd., Oxford (Regno Unito)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • S.Sortino; A.Mazzaglia; L.Monsù Scolaro; F. Marino Merlo; V. Valveri; M.T. Sciortino (literal)
Pagina inizio
  • 4256 (literal)
Pagina fine
  • 4265 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 27 (literal)
Rivista
Note
  • Scopu (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Dipartimento di Scienze Chimiche, Universita` di Catania, Catania, Italy; Istituto per lo Studio dei Materiali Nanostrutturati, ISMN-CNR, Unita` di Messina, Messina, Italy; Dipartimento di Chimica Inorganica, Chimica Analitica e Chimica Fisica, Universita` di Messina, Messina, Italy; Dipartimento di Scienze Microbiologiche, Genetiche e Molecolari, Universita` di Messina, Salita Sperone 31, 98166 Messina, Italy (literal)
Titolo
  • Nanoparticles of cationic amphiphilic cyclodextrins entangling anionic porphyrins as a carrioer sensitizer system in photodynamic cancer therapy (literal)
Abstract
  • The photodynamic activity of a carrier-sensitizer system consisting of heterotopic colloidal nanoparticles (diameter 100-1000 nm) of a cationic amphiphilic cyclodextrin, heptakis(2-o-amino-O-oligo(ethylene oxide)-6-hexylthio)-b-CD (SC6CDNH2) encapsulating the anionic 5,10,15,20-tetrakis(4-sulfonatophenyl)-21H,23H-porphyrin (TPPS) is investigated by an interdisciplinary approach involving the combination of time-resolved absorption and emission techniques with in vitro studies on cultured tumor cells. In a range of TPPS:SC6CDNH2 molar ratios between 1:10 and 1:50 these nanoparticles preserve the photodynamic properties of the entrapped photoactive agent. In fact, the triplet state of TPPS is efficiently populated, very long-lived and, as a consequence, able to produce singlet oxygen (the essential species for the photodynamic action) with quantum yield comparable to the free TPPS. Photodynamic efficacy of the carrier/sensitizer system is proven by in vitro studies on tumor Hela cells treated with TPPS:SC6CDNH2 at different molar ratio, showing significant cells death upon illumination with visible light. (literal)
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