PEGylated nanoparticles based on polyaspartamide: preparation, physico-chemical characterization and intracellular uptake (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• PEGylated nanoparticles based on polyaspartamide: preparation, physico-chemical characterization and intracellular uptake (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1021/bm060570c (literal)

Alternative label

• E.F. Capraro, G. Cavallaro, M.L. Bondì, D. Mandracchia, G. Giammona (2006)
  PEGylated nanoparticles based on polyaspartamide: preparation, physico-chemical characterization and intracellular uptake
  in Biomacromolecules; ACS, American chemical society, Washington, DC (Stati Uniti d'America)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• E.F. Capraro, G. Cavallaro, M.L. Bondì, D. Mandracchia, G. Giammona (literal)

Pagina inizio

• 3083 (literal)

Pagina fine

• 3092 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 7 (literal)

Rivista

• Biomacromolecules (Rivista)

Note

• Google Scholar (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• ISMN-CNR (literal)

Titolo

• PEGylated nanoparticles based on polyaspartamide: preparation, physico-chemical characterization and intracellular uptake (literal)

Abstract

• Nanoparticles with different surface PEGylation degree were prepared by using as starting material ?,?-poly(N-2-hydroxyethyl)-d,l-aspartamide (PHEA). PHEA was functionalized with a PEG amino-derivative for obtaining PHEA-PEG2000 copolymer. Both PHEA and PHEA-PEG2000 were derivatized with methacrylic anhydride (MA) for obtaining poly(hydroxyethylaspartamide methacrylated) (PHM) and poly(hydroxyethylaspartamide methacrylated)-PEGylated (PHM-PEG2000), respectively. Nanoparticles were obtained by UV irradiation of an inverse microemulsion, using as internal phase an aqueous solution of PHM alone or of the PHM/PHM-PEG2000 mixture at different weight ratio and as external phase a mixture of propylene carbonate and ethyl acetate. Obtained nanoparticles were characterized by FT-IR analysis, dimensional analysis, and TEM micrography. XPS analysis and zeta potential measurements demonstrated the presence of PEG onto the nanoparticle surface. Moreover, the partial degradation of nanoparticles in the presence of esterase as a function of time was demonstrated. Finally, nanoparticles did not possess any cytotoxic activity against K-562 cells and were able to escape from phagocytosis depending on the surface PEGylation degree. (literal)

Editore

• ACS, American chemical society (Editore)

Prodotto di

• Sintesi e crescita di film e superfici nanostrutturate (PM.P05.004.002) (Modulo)
• Istituto per lo studio dei materiali nanostrutturati (ISMN) (Istituto)

Autore CNR

• MARIA LUISA BONDI' (Unità di personale interno)

Incoming links:

Prodotto

• Istituto per lo studio dei materiali nanostrutturati (ISMN) (Istituto)
• Sintesi e crescita di film e superfici nanostrutturate (PM.P05.004.002) (Modulo)

Autore CNR di

• MARIA LUISA BONDI' (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Biomacromolecules (Rivista)

Editore di

• ACS, American chemical society (Editore)