Chemically Resolved Imaging of Biological Cells and Thin Films by Infrared Scanning Near-Field Optical Microscopy (IR-SNOM) (Articolo in rivista)

Type
Label
  • Chemically Resolved Imaging of Biological Cells and Thin Films by Infrared Scanning Near-Field Optical Microscopy (IR-SNOM) (Articolo in rivista) (literal)
Anno
  • 2003-01-01T00:00:00+01:00 (literal)
Alternative label
  • Cricenti A., Generosi R., Luce M., Perfetti P., Margaritondo G., Talley D., Sanghera Jas S., Aggarwal I.D., Tolk N.H. , Congiu-Castellano A., Rizzo M.A., Piston D.W. (2003)
    Chemically Resolved Imaging of Biological Cells and Thin Films by Infrared Scanning Near-Field Optical Microscopy (IR-SNOM)
    in Biophysical journal (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Cricenti A., Generosi R., Luce M., Perfetti P., Margaritondo G., Talley D., Sanghera Jas S., Aggarwal I.D., Tolk N.H. , Congiu-Castellano A., Rizzo M.A., Piston D.W. (literal)
Pagina inizio
  • 2705 (literal)
Pagina fine
  • 2710 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • Questo articolo dimostra la possibilita' di utilizzare lo SNOM nell'infrarosso con risoluzione al di sotto del limite di diffrazione. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 85 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • L'articolo descrive l'applicazione nell'infrarosso della microscopia ottica a campo vicino per lo studio di cellule biologiche. I risultati pubblicati dimostrano il raggiungimento di una risoluzione molto piu' piccola della lunghezza d'onda utilizzata e permettono di evidenziare i contributi chimici all'interno della cellula alle varie lunghezze d'onda utilizzate. (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • CNR - ISM, Roma EPFL, Lausanne, Switzerland Vanderbilt University, Nashville, USA Università di Roma La Sapienza 5 U.S. Naval Research Laboratory USA (literal)
Titolo
  • Chemically Resolved Imaging of Biological Cells and Thin Films by Infrared Scanning Near-Field Optical Microscopy (IR-SNOM) (literal)
Abstract
  • The infrared (IR) absorption of a biological system can potentially report on fundamentally important microchemical properties. For example, molecular IR profiles are known to change during increases in metabolic flux, protein phosphorylation, or proteolytic cleavage. However, practical implementation of intracellular IR imaging has been problematic because the diffraction limit of conventional infrared microscopy results in low spatial resolution. We have overcome this limitation by using an IR spectroscopic version of scanning near-field optical microscopy (SNOM), in conjunction with a tunable free-electron laser (FEL) source. The results presented here clearly reveal different chemical constituents in thin films and biological cells. The space distribution of specific chemical species was obtained by taking SNOM images at IR wavelengths (l) corresponding to stretch absorption bands of common biochemical bonds, such as the amide bond. In our SNOM implementation, this chemical sensitivity is combined with a lateral resolution of 0.1 mm (Hl/70), well below the diffraction limit of standard infrared microscopy. The potential applications of this approach touch virtually every aspect of the life sciences and medical research, as well as problems in materials science, chemistry, physics and environmental research. (literal)
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Autore CNR di
Prodotto
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Insieme di parole chiave di
data.CNR.it