Mass spectrometry approaches for the redox characterization of protein cysteine residues the case of the transcription factor Pax-8. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Mass spectrometry approaches for the redox characterization of protein cysteine residues the case of the transcription factor Pax-8. (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/S0076-6879(10)73012-3 (literal)

Alternative label

• Scaloni A, Tell G. (2010)
  Mass spectrometry approaches for the redox characterization of protein cysteine residues the case of the transcription factor Pax-8.
  in Methods in enzymology (Print); Academic Press, New York (Stati Uniti d'America)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Scaloni A, Tell G. (literal)

Pagina inizio

• 227 (literal)

Pagina fine

• 250 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.sciencedirect.com/science/article/pii/S0076687910730123 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 473 (literal)

Rivista

• Methods in enzymology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 24 (literal)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Proteomics and Mass Spectrometry Laboratory, ISPAAM, National Research Council, Naples, Italy. (literal)

Titolo

• Mass spectrometry approaches for the redox characterization of protein cysteine residues the case of the transcription factor Pax-8. (literal)

Abstract

• Regulation of protein structure and function by redox reactions has emerged as an exciting area of research study. The transduction of a redox signal into a biological response can be mediated in several ways, but a principal mechanism involves the modification of protein cysteine (Cys) residues. Several transcription factors, such as NF-kappaB, Egr-1, AP-1, and Pax, are regulated through redox-based mechanisms. Thus, redox regulation represents a key issue in specifically controlling gene expression. This study describes the combined use of MS procedures and protein-functional assays to investigate the redox state of a protein-regulating gene expression in thyroid, namely Pax-8, a member of the Pax family of transcription factors. Molecular characterization of the modified cysteine residues after various oxidative insults provided information on the mechanisms controlling protein-functional properties. (literal)

Editore

• Academic Press (Editore)

Prodotto di

• Metodologie genomiche e proteomiche applicate al sistema zootecnico ed agroindustriale (AG.P01.015.001) (Modulo)
• Institute for animal production system in mediterranean environment (ISPAAM) (Istituto)

Autore CNR

• ANDREA SCALONI (Persona)

Incoming links:

Autore CNR di

• ANDREA SCALONI (Persona)

Prodotto

• Institute for animal production system in mediterranean environment (ISPAAM) (Istituto)
• Metodologie genomiche e proteomiche applicate al sistema zootecnico ed agroindustriale (AG.P01.015.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Methods in enzymology (Rivista)

Editore di

• Academic Press (Editore)