The reductive desulfurization of Met and Cys residues in bovine RNAse A associated with the trans lipid formation in a mimetic model of biological membranes (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• The reductive desulfurization of Met and Cys residues in bovine RNAse A associated with the trans lipid formation in a mimetic model of biological membranes (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Alternative label

• Ferreri, C.; Chatgilialoglu, C.; Torreggiani, A.; Salzano, A. M.; Renzone, G.; Scaloni, A (2008)
  The reductive desulfurization of Met and Cys residues in bovine RNAse A associated with the trans lipid formation in a mimetic model of biological membranes
  in Journal of proteome research (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Ferreri, C.; Chatgilialoglu, C.; Torreggiani, A.; Salzano, A. M.; Renzone, G.; Scaloni, A (literal)

Pagina inizio

• 2007 (literal)

Pagina fine

• 2015 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 7 (literal)

Rivista

• Journal of proteome research (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• ISOF, Consiglio Nazionale delle Ricerche, via P. Gobetti 101, 40129 Bologna, Italy, and Proteomics & Mass Spectrometry Laboratory, ISPAAM, Consiglio Nazionale delle Ricerche, via Argine 1085, 80147 Napoli, Italy (literal)

Titolo

• The reductive desulfurization of Met and Cys residues in bovine RNAse A associated with the trans lipid formation in a mimetic model of biological membranes (literal)

Abstract

• Damage to bovine pancreatic RNase A, due to the Ho atom and/or solvated electron attack at protein sulfur-containing residues, was investigated by Raman spectroscopy and mass spectrometry techniques. To the already known desulfurization process affecting Met residues, novel reactivity was observed involving disulfide moieties, leading to the chemical transformation of Cys into Ala residues. Mapping experiments demonstrated that desulfurization selectively affected Met79, Cys110, Cys58 and Cys72 during first stages of reaction. While this reaction was performed on protein species added to large unilamellar vescicles, desulfurization yielded sulfur radicals able to induce a cis-trans isomerization of lipids at the onset of irradiation. These findings reveal new scenarios on reactions generated by radical stressing conditions, suggesting the need for specific assays and for future investigations to detect these modifications in proteins and lipids within challenged cells. (literal)

Prodotto di

• Modelli biomimetici di stress radicalico e biomarcatori correlati (PM.P06.006.001) (Modulo)
• Institute for organic syntheses and photoreactivity (ISOF) (Istituto)

Autore CNR

• CARLA FERRERI (Unità di personale interno)
• ARMIDA TORREGGIANI (Unità di personale interno)
• CHRYSSOSTOMOS CHATGILIALOGLU (Unità di personale interno)

Incoming links:

Prodotto

• Institute for organic syntheses and photoreactivity (ISOF) (Istituto)
• Modelli biomimetici di stress radicalico e biomarcatori correlati (PM.P06.006.001) (Modulo)

Autore CNR di

• CARLA FERRERI (Unità di personale interno)
• CHRYSSOSTOMOS CHATGILIALOGLU (Unità di personale interno)
• ARMIDA TORREGGIANI (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of proteome research (Rivista)