Synthesis and HSA binding characterisation of the water soluble 7-succinylpaclitaxel (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Synthesis and HSA binding characterisation of the water soluble 7-succinylpaclitaxel (Articolo in rivista) (literal)

Anno

• 2003-01-01T00:00:00+01:00 (literal)

Alternative label

• Battaglia A, Bertucci C, Bombardelli E, Cimitan S, Guerrini A, Morazzoni P, Riva A (2003)
  Synthesis and HSA binding characterisation of the water soluble 7-succinylpaclitaxel
  in European journal of medicinal chemistry
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Battaglia A, Bertucci C, Bombardelli E, Cimitan S, Guerrini A, Morazzoni P, Riva A (literal)

Pagina inizio

• 383 (literal)

Pagina fine

• 389 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 38 (literal)

Rivista

• European journal of medicinal chemistry (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Titolo

• Synthesis and HSA binding characterisation of the water soluble 7-succinylpaclitaxel (literal)

Abstract

• A water soluble paclitaxel analogue, the 7-hemisuccinylpaclitaxel, was synthesised and its binding to human serum albumin (HSA) was characterised by difference circular dichroism and optical biosensor methodologies. The carboxylate group was introduced at paclitaxel C-7 position to improve the drug water solubility without significantly changing the biological activity. The paclitaxel analogue showed a relatively low affinity to HSA (3.5 x 10(4) M-1), while no significant interactions were evidenced with selective markers for the most characterised binding sites on the carrier, suggesting a non-selective binding to low affinity binding sites. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved. (literal)

Prodotto di

• Sintesi e caratterizzazione mediante metodologie chimiche innovative, di scaffold molecolari per l'individuazione di nuove molecole biologicamente attive. (PM.P03.011.002) (Modulo)
• Institute for organic syntheses and photoreactivity (ISOF) (Istituto)

Autore CNR

• ANDREA GUERRINI (Persona)
• ARTURO BATTAGLIA (Unità di personale interno)

Incoming links:

Prodotto

• Institute for organic syntheses and photoreactivity (ISOF) (Istituto)
• Sintesi e caratterizzazione mediante metodologie chimiche innovative, di scaffold molecolari per l'individuazione di nuove molecole biologicamente attive. (PM.P03.011.002) (Modulo)

Autore CNR di

• ARTURO BATTAGLIA (Unità di personale interno)
• ANDREA GUERRINI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• European journal of medicinal chemistry (Rivista)