Drug target identification for neuronal apoptosis through a genome scale screening (Articolo in rivista)

Type
Label
  • Drug target identification for neuronal apoptosis through a genome scale screening (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Alternative label
  • Tendi EA, Cunsolo R, Bellia D, Messina RL, Paratore S, Calissano P, Cavallaro S (2010)
    Drug target identification for neuronal apoptosis through a genome scale screening
    in Current medicinal chemistry
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Tendi EA, Cunsolo R, Bellia D, Messina RL, Paratore S, Calissano P, Cavallaro S (literal)
Pagina inizio
  • 2906 (literal)
Pagina fine
  • 2920 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 17 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 26 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1Pfizer, Catania, Italy; 2University Hospital \"Policlinico Vittorio Emanuele\", Catania, Italy; 3Functional Genomics Center, Institute of Neurological Sciences, Italian National Research Council, Catania, Italy; 4European Brain Re- search Institute, Roma, Italy (literal)
Titolo
  • Drug target identification for neuronal apoptosis through a genome scale screening (literal)
Abstract
  • During normal nervous system development, physiologically appropriate neuronal apoptosis contributes to a sculpting process that removes approximately one-half of all neurons born during neurogenesis. However, neuronal apop- tosis subsequent to this developmental window is physiologically inappropriate for most systems and can contribute to neurodegenerative diseases. Neuronal apoptosis is characterized by specific morphological events and requires the activa- tion of an intrinsic transcriptional program. With the completion of genome sequencing in humans and model organisms, and the advent of DNA microarray technology, the transcriptional cascades and networks regulating neuronal apoptosis are being elucidated providing new potential pharmacological targets. This review will introduce the reader to this ge- nomic approach and illustrate with a few examples a methodological strategy for the rational selection of pharmacological targets and the development of neuroprotective agents. (literal)
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