A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease. (Articolo in rivista)

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  • A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease. (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.neurobiolaging.2009.11.021 (literal)
Alternative label
  • Krüger R, Sharma M, Riess O, Gasser T, Van Broeckhoven C, Theuns J, Aasly J, Annesi G, Bentivoglio AR, Brice A, Djarmati A, Elbaz A, Farrer M, Ferrarese C, Gibson JM, Hadjigeorgiou GM, Hattori N, Ioannidis JP, Jasinska-Myga B, Klein C, Lambert JC, Lesage (2010)
    A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease.
    in Neurobiology of aging
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Krüger R, Sharma M, Riess O, Gasser T, Van Broeckhoven C, Theuns J, Aasly J, Annesi G, Bentivoglio AR, Brice A, Djarmati A, Elbaz A, Farrer M, Ferrarese C, Gibson JM, Hadjigeorgiou GM, Hattori N, Ioannidis JP, Jasinska-Myga B, Klein C, Lambert JC, Lesage (literal)
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  • 548e9 (literal)
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  • http://www.sciencedirect.com/science/article/pii/S0197458009003911 (literal)
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  • 32 (literal)
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  • 9 (literal)
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  • 3 (literal)
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  • ISI Web of Science (WOS) (literal)
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  • Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, Germany b Medical Genetics, University of Tübingen, Germany c Laboratory of Neurogenetics, Insititute Born-Bunge, University of Antwerp, Antwerpen, Belgium d Department of Neurology, University of Trondheim, Norway e Institute of Neurological Sciences, National Research Council, Cosenza, Italy f Department of Neurology, Catholic University, Rome, Italy g Université Pierre et Marie Curie-Paris, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris, France h INSERM, U975, Paris, France i Cnrs, UMR 7225, Paris, France j AP-HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, F-75013, Paris, France k Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Germany l INSERM, Unit 708, F-75013, Paris, France m UPMC Univ Paris 06, U708, Neuroepidemiology, F-75005, Paris, France n Department of Genetics, Mayo Clinic, Jacksonville, USA o Department of Neuroscience, Section of Neurology, University of Milano-Bicocca San Gerardo Hospital, Monza, Italy p The Dublin Neurological Institute at the Mater Misericordiae University Hospital, Clinical Investigator at the Conway Institute, University College Dublin, Ireland q Department of Neurology, Royal Victoria Hospital, Belfast, Ireland r Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, School of Medicine, Larissa, Greece s Institute of Biomedical Research & Technology, CERETETH, Larissa, Greece t Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan u Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece v Department of Neurology, Medical University of Silesia, Katowice, Poland w Department of Neurology, Chushang Show-Chwan Hospital, Taiwan x Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular & Physical Sciences, Griffith University, Nathan, QLD, Australia y University of Queensland, Centre for Clinical Research, Royal Brisbane Hospital, Australia z Institute of Neurology, University Magna Graecia, Catanzaro, Italy A Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine, Japan B Department of Neurology, Singapore General Hospital, National Neuroscience Institute and Duke-NUS Graduate Medical School, Singapore C Department of Medical Epidemiology and Biostatistics and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden D Department of Neurology, Mayo Clinic Jacksonville, USA E Department of Neurology, Mayo Clinic, Rochester, MN, United States F INSERM, U744, Université de Lille 2, Institut Pasteur de Lille, BP 245,1, rue du professeur Calmette, Lille cedex, France (literal)
Titolo
  • A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease. (literal)
Abstract
  • High-profile studies have provided conflicting results regarding the involvement of the Omi/HtrA2 gene in Parkinson's disease (PD) susceptibility. Therefore, we performed a large-scale analysis of the association of common Omi/HtrA2 variants in the Genetic Epidemiology of Parkinson's disease (GEO-PD) consortium. GEO-PD sites provided clinical and genetic data including affection status, gender, ethnicity, age at study, age at examination (all subjects); age at onset and family history of PD (patients). Genotyping was performed for the five most informative SNPs spanning the Omi/HtrA2 gene in approximately 2-3 kb intervals (rs10779958, rs2231250, rs72470544, rs1183739, rs2241028). Fixed as well as random effect models were used to provide summary risk estimates of Omi/HtrA2 variants. The 20 GEO-PD sites provided data for 6378 cases and 8880 controls. No overall significant associations for the five Omi/HtrA2 SNPs and PD were observed using either fixed effect or random effect models. The summary odds ratios ranged between 0.98 and 1.08 and the estimates of between-study heterogeneity were not large (non-significant Q statistics for all 5 SNPs; I2 estimates 0-28%). Trends for association were seen for participants of Scandinavian descent for rs2241028 (OR 1.41, p = 0.04) and for rs1183739 for age at examination (cut-off 65 years; OR 1.17, p = 0.02), but these would not be significant after adjusting for multiple comparisons and their Bayes factors were only modest. This largest association study performed to define the role of any gene in the pathogenesis of Parkinson's disease revealed no overall strong association of Omi/HtrA2 variants with PD in populations worldwide. (literal)
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