Electroencephalographic effects induced by choline pivaloyl esters in scopolamine-treated or nucleus basalis magnocellularis lesioned rats. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Electroencephalographic effects induced by choline pivaloyl esters in scopolamine-treated or nucleus basalis magnocellularis lesioned rats. (Articolo in rivista) (literal)

Anno

• 2004-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.pbb.2004.04.031 (literal)

Alternative label

• Rispoli V, Rotiroti D, Carelli V, Liberatore F, Scipione L, Marra R, Tortorella S, Di Rienzo B. (2004)
  Electroencephalographic effects induced by choline pivaloyl esters in scopolamine-treated or nucleus basalis magnocellularis lesioned rats.
  in Pharmacology, biochemistry and behavior
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Rispoli V, Rotiroti D, Carelli V, Liberatore F, Scipione L, Marra R, Tortorella S, Di Rienzo B. (literal)

Pagina inizio

• 667 (literal)

Pagina fine

• 673 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 78 (literal)

Rivista

• Pharmacology, biochemistry and behavior (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 4 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Pharmacobiological Sciences, University of Catanzaro, ''Magna Græcia'', Complesso ''Nin?` Barbieri'', I-88021 Roccelletta di Borgia (CZ), Italy; Department of ''Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive'', University of Rome ''La Sapienza'', Piazzale Aldo Moro 5, I-00185 Rome, Italy; CNR Institute of Neurological Sciences, I-88021 Roccelletta di Borgia, Catanzaro, Italy (literal)

Titolo

• Electroencephalographic effects induced by choline pivaloyl esters in scopolamine-treated or nucleus basalis magnocellularis lesioned rats. (literal)

Abstract

• The electroencephalographic (EEG) effects of two choline pivaloyl esters, [2-(2,2-dimethylpropionyloxy)ethyl]trimethylammonium iodide (1) and [2-(2,2-dimethylpropionyloxy)ethyl]trimethylammonium 2,2-dimethylpropionate (2), were evaluated in scopolamine-treated or nucleus basalis magnocellularis (NBM) lesioned rats. In scopolamine-treated animals, Compounds 1 and 2 prevented or reduced EEG effects, such as increased amplitude of total spectra and high-voltage spindle (HVS) activity as well. Furthermore, choline esters showed a noticeable effectiveness in reversing the EEG changes produced in rats by AMPA-induced lesion of NBM. Indeed, Compounds 1 and 2 were able to induce EEG desynchronisation, a significant decrease in the total EEG power (0.25-16 Hz) and in the lower frequency delta and theta bands (0.25-3 and 3-6 Hz, respectively). The EEG effects produced by Compounds 1 and 2 were well comparable with that evoked by Tacrine, used as a reference compound. The results of the present work allow us to put forward the hypothesis that the EEG effects observed are most likely mediated through the stimulation of the cholinergic neurotransmission ensuing from enhanced cerebral levels of acetylcholine (ACh) consequent upon acetylcholinesterase (AChE) inhibition by choline pivaloyl esters. Copyright 2004 Elsevier Inc. (literal)

Prodotto di

• Farmacologia delle malattie ereditarie del sistema nervoso (ME.P02.014.001) (Modulo)
• Institute of neurological sciences (ISN) (Istituto)

Autore CNR

• ROSARIO MARRA (Persona)
• DOMENICANTONIO ROTIROTI (Unità di personale esterno)

Incoming links:

Autore CNR di

• DOMENICANTONIO ROTIROTI (Unità di personale esterno)
• ROSARIO MARRA (Persona)

Prodotto

• Institute of neurological sciences (ISN) (Istituto)
• Farmacologia delle malattie ereditarie del sistema nervoso (ME.P02.014.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Pharmacology, biochemistry and behavior (Rivista)