http://www.cnr.it/ontology/cnr/individuo/prodotto/ID50162

Gender-related effect of clinical and genetic variables on the cognitive impairment in multiple sclerosis. (Articolo in rivista)

Type

Label

Gender-related effect of clinical and genetic variables on the cognitive impairment in multiple sclerosis. (Articolo in rivista) (literal)

Anno

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

Alternative label

Savettieri G,Messina D,Andreoli V,Bonavita S,Caltagirone C,Cittadella R,Farina D,Fazio MC,Girlanda P,Le Pira F,Liguori M,Lugaresi A,Nocentini U,ReggioA,Salemi G,Tedeschi G,Trojano M,Quattrone A. (2004)
Gender-related effect of clinical and genetic variables on the cognitive impairment in multiple sclerosis.
in Journal of neurology (Print)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Savettieri G,Messina D,Andreoli V,Bonavita S,Caltagirone C,Cittadella R,Farina D,Fazio MC,Girlanda P,Le Pira F,Liguori M,Lugaresi A,Nocentini U,ReggioA,Salemi G,Tedeschi G,Trojano M,Quattrone A. (literal)

Pagina inizio

Pagina fine

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

Rivista

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

Note

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Institute of Neuropsychiatry University of Palermo Palermo, Italy; Institute of Neurological Sciences National Research Council Piano Lago di Mangone Cosenza, Italy; Dept. of Neurological Sciences 2nd University of Naples Naples, Italy; Cattedra di Neurologia and I.R.C.C.S. Fondazione \"S. Lucia\" University of Rome \"Tor Vergata\" Rome, Italy; Dept. of Oncology & Neurosciences University \"Gabriele d'Annunzio\" Chieti, Italy; Dept. of Neurosciences, Psychiatry & Anesthesiology University of Messina Messina, Italy; Dept. of Neurological Sciences University of Catania Catania, Italy; Dept. of Neurological & Psychiatric Sciences University of Bari Bari, Italy; Institute of Neurology University Magna Graecia Catanzaro, Italy; Clinica Neurologica Policlinico Mater Domini Via T. Campanella (literal)

Titolo

Gender-related effect of clinical and genetic variables on the cognitive impairment in multiple sclerosis. (literal)

Abstract

Cognitive impairment may occur at any time during the course of multiple sclerosis rosis (MS), and it is often a major cause of disability in patients with the disease. The APOE-?4 allele is the major known genetic risk factor for late onset familial and sporadic Alzheimer's Disease (AD), and it seems to be implicated in cognitive decline in normal elderly persons. Objective To investigate the clinical and genetic variables that can be associated with the cognitive decline in patients with MS. Methods Five-hundred and three patients with clinically definite MS underwent a battery of neuropsychological tests and, according to the number of failed tests, were divided into cognitively normal and impaired.All patients were genotyped for APOE gene polymorphisms. Results Fifty-six percent of MS patients showed, to different extents, cognitive impairment. Cognitive decline was predominant in men and was associated with disease duration,Kurtzke Expanded Disability Status Scale (EDSS) score, a low level of education, and, interestingly, the ?4 allele of the APOE gene. By contrast, cognitive impairment in women was independent of any investigated variable. Conclusion The findings demonstrate that clinical and genetic factors play a role in men affected by MS developing cognitive impairment. (literal)

Prodotto di