The entity of young onset primary cervical dystonia (Articolo in rivista)

Type
Label
  • The entity of young onset primary cervical dystonia (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Alternative label
  • Vasiliki Koukouni, MD 1, Davide Martino, MD 1 2, Gennarina Arabia, MD 1 3, Niall P. Quinn, MD 1, Kailash P. Bhatia, MD 1 (2007)
    The entity of young onset primary cervical dystonia
    in Movement disorders
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Vasiliki Koukouni, MD 1, Davide Martino, MD 1 2, Gennarina Arabia, MD 1 3, Niall P. Quinn, MD 1, Kailash P. Bhatia, MD 1 (literal)
Pagina inizio
  • 843 (literal)
Pagina fine
  • 847 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 22(6) (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1 Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, United Kingdom 2 Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy 3 Institute of Neurological Sciences, National Research Council, Cosenza, Italy (literal)
Titolo
  • The entity of young onset primary cervical dystonia (literal)
Abstract
  • Primary cervical dystonia is typically an adult onset condition with symptom onset usually in the fifth and sixth decade. Young onset (<28 years) is uncommon. We report 76 patients with cervical dystonia as a presenting or predominant feature, with disease onset before the age of 28. Male to female ratio was 1.24:1 and the mean onset age was 21 (3-28) years. A family history of tremor and/or dystonia was noted in 26.3%. Depression and anxiety attacks were present in 23.7%.Prior injury or surgery involving the neck was noted in 17.1%. 23 (30.3%) experienced spontaneous partial or complete remissions within the first 5 years of onset, but all relapsed. Cervical dystonia was predominantly rotational torticollis. 30% developed extra-nuchal dystonia and tremor affecting contiguous parts but in only one there was spread to affect the legs. All 15 patients tested for the DYT1 gene were negative. 74% responded favorably to botulinum toxin injections, whereas none of the 13 patients treated with L-Dopa preparations had a beneficial response. The distinctive features of this entity are discussed. © 2007 Movement Disorder Society (literal)
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