Group I metabotropic glutamate receptors: a role in neurodevelopmental disorders? (Articolo in rivista)

Type
Label
  • Group I metabotropic glutamate receptors: a role in neurodevelopmental disorders? (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1007/s12035-007-0022-1 (literal)
Alternative label
  • Catania MV, D'Antoni S, Bonaccorso CM, Aronica E, Bear MF, Nicoletti F. (2007)
    Group I metabotropic glutamate receptors: a role in neurodevelopmental disorders?
    in Molecular neurobiology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Catania MV, D'Antoni S, Bonaccorso CM, Aronica E, Bear MF, Nicoletti F. (literal)
Pagina inizio
  • 298 (literal)
Pagina fine
  • 307 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 35 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 10 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • Pubblicazione scientifica- invited review (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • ISN-CNR, Oasi Maria SS-Troina (EN), Massachusetts Institute of Technology, Boston USA, University of Amsterda, University of Rome-La Sapienza (literal)
Titolo
  • Group I metabotropic glutamate receptors: a role in neurodevelopmental disorders? (literal)
Abstract
  • Group I metabotropic glutamate receptors (mGlu1 and mGlu5) are coupled to polyphosphoinositide hydrolysis and are involved in activity-dependent forms of synaptic plasticity, both during development and in the adult life. Group I mGlu receptors can also regulate proliferation, differentiation, and survival of neural stem/progenitor cells, which further support their role in brain development. An exaggerated response to activation of mGlu5 receptors may underlie synaptic dysfunction in Fragile X syndrome, the most common inherited form of mental retardation. In addition, group I mGlu receptors are overexpressed in dysplastic neurons of focal cortical dysplasia and hemimegaloencephaly, which are disorders of cortical development associated with chronic epilepsy. Drugs that block the activity of group I mGlu receptors (in particular, mGlu5 receptors) are potentially helpful for the treatment of Fragile X syndrome and perhaps other neurodevelopmental disorders. (literal)
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Prodotto
Autore CNR di
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Insieme di parole chiave di
data.CNR.it