http://www.cnr.it/ontology/cnr/individuo/prodotto/ID50051
Fas antigen and sporadic Alzheimer's disease in Southern Italy:evaluation of two polymorphisms in the TNFRSF6 gene. (Articolo in rivista)
- Type
- Label
- Fas antigen and sporadic Alzheimer's disease in Southern Italy:evaluation of two polymorphisms in the TNFRSF6 gene. (Articolo in rivista) (literal)
- Anno
- 2007-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1007/s11064-007-9329-6 (literal)
- Alternative label
Virginia Andreoli, Giuseppe Nicoletti, Nelide Romeo, Francesca Condino, Antonella La Russa, Maria Liguori, Ida Manna, Patrizia Spadafora, Aldo Quattrone, Rita Cittadella. (2007)
Fas antigen and sporadic Alzheimer's disease in Southern Italy:evaluation of two polymorphisms in the TNFRSF6 gene.
in Neurochemical research
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Virginia Andreoli, Giuseppe Nicoletti, Nelide Romeo, Francesca Condino, Antonella La Russa, Maria Liguori, Ida Manna, Patrizia Spadafora, Aldo Quattrone, Rita Cittadella. (literal)
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- Note
- ISI Web of Science (WOS) (literal)
- Scopu (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza;
Institute of Neurology , University Magna Graecia, Catanzaro, Italy. (literal)
- Titolo
- Fas antigen and sporadic Alzheimer's disease in Southern Italy:evaluation of two polymorphisms in the TNFRSF6 gene. (literal)
- Abstract
- Tumor Necrosis Factor Receptor Super Family 6 gene (TNFRSF6), also known as FAS, encodes the Fas antigen, a cell surface receptor mediating cell apoptosis, situated on chromosome 10q located near the region of linkage to sporadic Alzheimers disease (sAD). FAS levels have been reported elevated in the brain of AD patients. Due to both positional and pathobiological criteria, the association of the FAS antigen with this pathology is of great interest. We have tested two SNPs in the FAS gene in 223 Italian patients with non-familial AD from Southern Italy (Calabria region) and 211 healthy control subjects. No significant differences in allelic and genotypic distributions were found between cases and controls, or late and early-onset AD patients, thus suggesting that these polymorphisms do not represent an AD risk factor in our population. (literal)
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