Apoptosis and in vitro Alzheimer disease neuronal models (Articolo in rivista)

Type
Label
  • Apoptosis and in vitro Alzheimer disease neuronal models (Articolo in rivista) (literal)
Anno
  • 2009-01-01T00:00:00+01:00 (literal)
Alternative label
  • Calissano P., Matrone C., Amadoro G. (2009)
    Apoptosis and in vitro Alzheimer disease neuronal models
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Calissano P., Matrone C., Amadoro G. (literal)
Pagina inizio
  • 163 (literal)
Pagina fine
  • 169 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 2(2): (literal)
Note
  • ISI Web of Science (WOS) (literal)
Titolo
  • Apoptosis and in vitro Alzheimer disease neuronal models (literal)
Abstract
  • Alzheimer disease (AD) is a human neurodegenerative disease characterized by co-existence of extracellular senile plaques (SP) and neurofibrillary tangles (NFT) associated with an extensive neuronal loss, primarily in the cerebral cortex and hippocampus. Several studies suggest that caspase(s)-mediated neuronal death occurs in cellular and animal AD models as well as in human brains of affected patients, although an etiologic role of apoptosis in such neurodegenerative disorder is still debated. This review summarizes the experimental evidences corroborating the possible involvement of apoptosis in AD pathogenesis and discusses the usefulness of ad hoc devised in vitro approaches to study how caspase(s), amyloidogenic processing and tau metabolism might reciprocally interact leading to neuronal death. (literal)
Prodotto di
Autore CNR

Incoming links:


Autore CNR di
Prodotto
data.CNR.it